Foxa2 - forkhead box A2 Gene

Also Known as Hnf3b; Tcf3b; Hnf-3b; Tcf-3b; HNF3beta; HNF3-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15376

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of detection of glucose; negative regulation of Glucokinase activity; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of neuron differentiation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; endoderm; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2). [provided by Alliance of Genome Resources, Apr 2022]

Foxa2 Products (3)

mRNA Protein Name
NM_001291065.1 NP_001277994.1 hepatocyte nuclear factor 3-beta isoform a
NM_001291067.1 NP_001277996.1 hepatocyte nuclear factor 3-beta isoform c
NM_010446.3 NP_034576.2 hepatocyte nuclear factor 3-beta isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11875061 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
11914369 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10859308 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11875061 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12488434 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22780989 MGI
enables double-stranded DNA binding IGI
IGI: Inferred from genetic interaction
23117660 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20609350 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11914369 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
18076286 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within anatomical structure morphogenesis IGI
IGI: Inferred from genetic interaction
9226455 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within cell development IMP
IMP: Inferred from mutant phenotype
15680365 MGI
acts upstream of or within cell differentiation in hindbrain IGI
IGI: Inferred from genetic interaction
17922007 MGI
acts upstream of or within cell differentiation in hindbrain IMP
IMP: Inferred from mutant phenotype
17922007 MGI
acts upstream of or within cell fate specification IDA
IDA: Inferred from direct assay
18076286 MGI
acts upstream of or within cellular response to cadmium ion IDA
IDA: Inferred from direct assay
15219627 MGI
acts upstream of or within connective tissue development IGI
IGI: Inferred from genetic interaction
23383217 MGI
acts upstream of dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
17596284 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
18076286 MGI
acts upstream of or within dorsal/ventral neural tube patterning IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
9226455 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within ectoderm formation IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
15680365 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IGI
IGI: Inferred from genetic interaction
15668254 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
29659575 MGI
involved in glucose mediated signaling pathway IDA
IDA: Inferred from direct assay
11875061 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9152011 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
15668254 MGI
acts upstream of or within lung epithelial cell differentiation IGI
IGI: Inferred from genetic interaction
15668254 MGI
acts upstream of mesendoderm development IMP
IMP: Inferred from mutant phenotype
26494787 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
17922007 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11875061 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
17922007 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
17596284 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
17922007 MGI
acts upstream of or within neuron fate specification IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
17922007 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
10498685 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11291865 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
17596284 MGI
involved in positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in positive regulation of gastrulation IMP
IMP: Inferred from mutant phenotype
11291865 MGI
acts upstream of or within positive regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
17922007 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
23383217 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10859308 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11875061 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15539431 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
9152011 MGI
involved in positive regulation of transcription by RNA polymerase III IMP
IMP: Inferred from mutant phenotype
15737987 MGI
acts upstream of or within primitive streak formation IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in primitive streak formation IMP
IMP: Inferred from mutant phenotype
11291865 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12488434 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
17596284 MGI
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
11875061 MGI
acts upstream of or within regulation of lipid metabolic process IDA
IDA: Inferred from direct assay
22737085 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
22737085 MGI
acts upstream of or within regulation of steroid metabolic process IDA
IDA: Inferred from direct assay
22737085 MGI
acts upstream of or within regulation of steroid metabolic process IMP
IMP: Inferred from mutant phenotype
22737085 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
23383217 MGI
acts upstream of or within somite rostral/caudal axis specification IMP
IMP: Inferred from mutant phenotype
11291865 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10859308 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
8813084 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
26494787 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 3-beta

  • HNF-3-beta

  • forkhead box protein A2

  • hepatocyte nuclear factor 3 beta (winged helix transcription factor)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-168534 WX-02-23 99.88% Unkown
HY-RS05037 FOXA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174679 Human FOXA2 mRNA / Unkown
HY-RS18820 Foxa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25310 Foxa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxa2 NCBI NCBI:3170