EFNB2 - ephrin B2 Gene

Also Known as HTKL; EPLG5; Htk-L; LERK5; ephrin-B2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1948

About EFNB2

Cytogenetic location: 13q33.3 Genomic coordinates (GRCh38): 13:106,489,745-106,535,662 (from NCBI)

This gene has 2 transcripts (splice variants), 221 orthologues and 7 paralogues. Ubiquitous expression in lung (RPKM 8.5), colon (RPKM 7.4) and 23 other tissues.

Summary

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EphB4 and EphA3 receptors. [provided by RefSeq, Jul 2008]

EFNB2 Products (4)

mRNA	Protein	Name
NM_001372056.1	NP_001358985.1	ephrin-B2 isoform 2
NM_001372057.1	NP_001358986.1	ephrin-B2 isoform 3
NM_001372058.1	NP_001358987.1	ephrin-B2 isoform 4 precursor
NM_004093.4	NP_004084.1	ephrin-B2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	16867992	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12606549	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	12734395	GOA
involved in cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	12734395	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	12734395	GOA
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	10066262	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	26268439	GOA
involved in regulation of chemotaxis	IDA IDA: Inferred from direct assay	12734395	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	17251577	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNB2 Protein Structure

Ephrin

0
100
200
300
333 a.a.

Protein Preferred Names	Protein Names
ephrin-B2	HTK ligand

EFNB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	EFNB2	P52799	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Cross	EFNB2	P52799	G	Nipah virus	Q9IH62	SPR	18488039
Intra	EFNB2	P52799	EPHB4	Homo sapiens	P54760	SPR	26481148
Intra	EFNB2	P52799	EPHB4	Homo sapiens	P54760	Anti Tag CoIP	33961781
Intra	EFNB2	P52799	EPHB4	Homo sapiens	P54760	Anti Tag CoIP	28514442
Intra	EFNB2	P52799	NCK2	Homo sapiens	O43639	CD	12606549
Intra	EFNB2	P52799	NCK2	Homo sapiens	O43639	NMR	15764601
Intra	EFNB2	P52799	NCK2	Homo sapiens	O43639	NMR	12606549
Cross	EFNB2	P52799	G	Hendra virus	O89343	X-Ray Diffraction	18488039
Cross	EFNB2	P52799	G	Hendra virus	O89343	GMS	18488039

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNB2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70377	Ephrin-B2/EFNB2 Protein, Human (HEK293, His)	P52799 (I28-A229)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73015	Ephrin-B2/EFNB2 Protein, Human (HEK293)	P52799 (I28-A229)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77645	Ephrin-B2/EFNB2 Protein, Human (HEK293, Fc)	P52799 (I28-A229)	≥ 95%, as determined by Bis-Tris PAGE.

EFNB2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83640	Ephrin B2 Antibody (YA3385)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Nipah Virus Encephalitis	Equine Morbillivirus
Pyogenic Granuloma	Lobular Capillary Hemangioma Granuloma Pyogenic Granuloma Pyogenicum Granuloma Telangiectaticum Of Skin Pyogenic Granuloma Of Skin Lobular Capillary Haemangioma Of Skin
Lymphatic Malformation 12	Central Conducting Lymphatic Anomaly LMPHM12 Ccla Lymphatic Malformation-7 Doid:0081030
Kaposi Sarcoma	Kaposi'S Sarcoma Kaposi Sarcoma, Susceptibility To Kaposi'S Sarcoma Of Lung Kaposi'S Sarcoma Of Palate Kaposi'S Sarcoma Of Soft Tissue Kaposi'S Sarcoma-Associated Herpesvirus Multiple Idiopathic Pigmented Hemangiosarcoma Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To African Lymphadenopathic Kaposi'S Sarcoma Anal Kaposi'S Sarcoma Cardiac Kaposi'S Sarcoma Central Nervous System Kaposi'S Sarcoma Conjunctival Kaposi'S Sarcoma Corneal Kaposi'S Sarcoma Cutaneous Kaposi'S Sarcoma Esophageal Kaposi'S Sarcoma Gallbladder Kaposi'S Sarcoma Gastric Kaposi'S Sarcoma Intestinal Kaposi'S Sarcoma Kaposi'S Sarcoma Of Anus Kaposi'S Sarcoma Of Central Nervous System Kaposi'S Sarcoma Of Conjunctiva Kaposi'S Sarcoma Of Cornea Kaposi'S Sarcoma Of Esophagus Kaposi'S Sarcoma Of Gastrointestinal Sites Kaposi'S Sarcoma Of Heart Kaposi'S Sarcoma Of Lymph Nodes Kaposi'S Sarcoma Of Penis Kaposi'S Sarcoma Of Skin Kaposi'S Sarcoma Of Soft Tissues Kaposi'S Sarcoma Of The Cns Kaposi'S Sarcoma Of The Gallbladder Kaposi'S Sarcoma Of The Prostate Kaposi'S Sarcoma, Lung Kaposi'S Sarcoma, Skin Lymph Node Kaposi'S Sarcoma Lymphadenopathic Kaposi'S Sarcoma Palate Kaposi'S Sarcoma Penis Kaposi'S Sarcoma Prostate Kaposi'S Sarcoma Pulmonary Kaposi'S Sarcoma Soft Tissue Kaposi'S Sarcoma Hhv8 Human Herpesvirus 8 Kshv Kaposi Sarcoma Herpesvirus Mediterranean Kaposi Sarcoma Non Aids Related Kaposi Sarcoma Sarcoma, Kaposi Sarcoma, Kaposi, Susceptibility To Non-Aids-Related Kaposi Sarcoma Angiolymphoid Hyperplasia Angiofollicular Ganglionic Hyperplasia Multi-Centric Castleman'S Disease
Craniofrontonasal Syndrome	Craniofrontonasal Dysplasia CFNS Cfnd Craniofrontonasal Dysostosis Craniofrontonasal Dystosis Dysplasia, Craniofrontonasal
Arteriovenous Malformation	Arteriovenous Malformations Arteriovenous Hemangioma Cirsoid Aneurysm Racemose Aneurysm Racemose Angioma Racemose Hemangioma Congenital Arteriovenous Malformation
Chylothorax, Congenital	Congenital Chylothorax Hydrothorax, Congenital
Ectopic Thymus
Lymphedema-Distichiasis Syndrome	Lymphedema With Distichiasis Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus LPHDST Distichiasis-Lymphedema Syndrome Lymphedema Distichiasis Syndrome Hereditary Lymphedema-Distichiasis Syndrome Lymphedema Distichiasis
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Hereditary Lymphedema	Milroy Disease
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Inner Ear Disease	Labyrinthine Dysfunction Diseases Of Inner Ear Labyrinthine Disease Abnormality Of The Inner Ear Labyrinth Diseases Labyrinthine Disorder Nonfunctioning Labyrinth Labyrinthine Loss Of Function Labyrinthine Syndrome Labyrinthine Disorder Nos
Persistent Hyperplastic Primary Vitreous	Congenital Retinal Detachment Ncrna Disease Non-Syndromic Congenital Retinal Non-Attachment Pfvs Phpv Persistent Fetal Vasculature Syndrome
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS04198	EFNB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17275	Efnb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23729	Efnb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EFNB2	VGNC	VGNC:28360
Rattus norvegicus	EFNB2	RGD	RGD:1309497
Mus musculus	EFNB2	MGD	MGI:105097
Macaca mulatta	EFNB2	VGNC	VGNC:72170
Canis familiaris	EFNB2	VGNC	VGNC:40229
Felis catus	EFNB2	VGNC	VGNC:61750
Others	EFNB2	NCBI