HTATSF1 - HIV-1 Tat specific factor 1 Gene

Also Known as TATSF1; TAT-SF1; dJ196E23.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27336

About HTATSF1

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,497,229-136,512,346 (from NCBI)

This gene has 4 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in adrenal (RPKM 48.7), brain (RPKM 28.0) and 25 other tissues.

Summary

The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]

HTATSF1 Products (2)

mRNA Protein Name
NM_001163280.2 NP_001156752.1 HIV Tat-specific factor 1
NM_014500.5 NP_055315.2 HIV Tat-specific factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables chromatin-protein adaptor activity IDA
IDA: Inferred from direct assay
35597237 GOA
enables poly-ADP-D-ribose modification-dependent protein binding IDA
IDA: Inferred from direct assay
35597237 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17332742 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in U2-type prespliceosome assembly IDA
IDA: Inferred from direct assay
32494006 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
35597237 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
32494006 GOA
involved in protein localization to site of double-strand break IDA
IDA: Inferred from direct assay
35597237 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
is active in site of double-strand break IDA
IDA: Inferred from direct assay
35597237 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTATSF1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (135 - 212)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (291 - 344)

  • 0
  • 200
  • 400
  • 600
  • 755 a.a.
Protein Preferred Names Protein Names

HIV Tat-specific factor 1

  • HIV TAT specific factor 1

HTATSF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
HTATSF1 O43719 SF3B1 Homo sapiens O75533-1
ITC
30567737
Intra
HTATSF1 O43719 SF3B1 Homo sapiens O75533-1
X-Ray Diffraction
30567737
Intra
HTATSF1 O43719 SF3B1 Homo sapiens O75533-1
Pull Down
30567737
Intra
HTATSF1 O43719 SF3B1 Homo sapiens O75533-1
Anti Bait CoIP
30567737
Cross: Cross-species interaction Intra: Intraspecies interaction

HTATSF1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83141 Tat SF1 Antibody (YA2886) WB, IHC-P, ICC/IF, IP Human, Mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06454 HTATSF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HTATSF1 MGD MGI:1919709
Bos taurus HTATSF1 VGNC VGNC:29990
Macaca mulatta HTATSF1 VGNC VGNC:73535
Felis catus HTATSF1 VGNC VGNC:67666
Canis familiaris HTATSF1 VGNC VGNC:41822
Rattus norvegicus HTATSF1 RGD RGD:1563377
Others HTATSF1 NCBI