MRAP - melanocortin 2 receptor accessory protein Gene

Also Known as B27; FALP; FGD2; GCCD2; C21orf61

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56246

About MRAP

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:32,291,813-32,314,784 (from NCBI)

This gene has 4 transcripts (splice variants), 69 orthologues and is associated with 3 phenotypes. Broad expression in fat (RPKM 19.3), adrenal (RPKM 18.8) and 20 other tissues.

Summary

This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of Other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]

MRAP Products (4)

mRNA	Protein	Name
NM_001285394.2	NP_001272323.1	melanocortin-2 receptor accessory protein isoform c
NM_001379228.1	NP_001366157.1	melanocortin-2 receptor accessory protein isoform alpha
NM_178817.4	NP_848932.1	melanocortin-2 receptor accessory protein isoform alpha
NM_206898.2	NP_996781.1	melanocortin-2 receptor accessory protein isoform beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables corticotropin hormone receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18077336	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18077336	GOA
enables type 1 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 3 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 4 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 5 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19329486	GOA
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19329486	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19329486	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRAP Protein Structure

MRAP

0
100
172 a.a.

Protein Preferred Names	Protein Names
melanocortin-2 receptor accessory protein	fat cell-specific low molecular weight protein

MRAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MRAP	Q8TCY5	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	MRAP	Q8TCY5	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	MRAP	Q8TCY5	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	MRAP	Q8TCY5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MRAP	Q8TCY5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MRAP	Q8TCY5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MRAP	Q8TCY5	MC4R	Homo sapiens	P32245	Anti Tag CoIP	19329486
Intra	MRAP	Q8TCY5	MC2R	Homo sapiens	Q01718	Ub Reconstruction	28298427
Intra	MRAP	Q8TCY5	MC2R	Homo sapiens	Q01718	Anti Tag CoIP	18077336
Intra	MRAP	Q8TCY5	MC5R	Homo sapiens	P33032	Anti Tag CoIP	19329486
Intra	MRAP	Q8TCY5	MC3R	Homo sapiens	P41968	Anti Tag CoIP	19329486
Intra	MRAP	Q8TCY5	MRAP	Homo sapiens	Q8TCY5	BiFC	20371771
Intra	MRAP	Q8TCY5	RPL15	Homo sapiens	P61313	Crosslink	30021884
Intra	MRAP	Q8TCY5	MRAP	Homo sapiens	Q8TCY5	Anti Tag CoIP	18077336

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MRAP Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P74743	MRAP Protein, Human (HEK293, hFc)	Q8TCY5-4 (Y59-S172)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Glucocorticoid Deficiency 2	GCCD2 Familial Glucocorticoid Deficiency 2 Fgd2
Glucocorticoid Deficiency 1	Acth Resistance Glucocorticoid Deficiency, Due To Acth Unresponsiveness GCCD1 Familial Glucocorticoid Deficiency 1 Fgd1 Adrenal Unresponsiveness To Acth Hereditary Unresponsiveness To Adrenocorticotropic Hormone Isolated Glucocorticoid Deficiency
Familial Glucocorticoid Deficiency	Glucocorticoid Deficiency Acth Resistance Adrenal Unresponsiveness To Acth Hereditary Unresponsiveness To Adrenocorticotropic Hormone Isolated Glucocorticoid Deficiency Glucocorticoid Deficiency, Familial Glucocorticoid Deficiency 1
Juvenile Ankylosing Spondylitis
Perforated Corneal Ulcer
Hypophosphatasia, Childhood	Childhood Hypophosphatasia Childhood-Onset Hypophosphatasia HPPC Childhood-Onset Phosphoethanolaminuria Childhood-Onset Rathburn Disease Childhood-Onset Rathbun Disease
Iridocyclitis	Primary Iridocyclitis
Lipoid Congenital Adrenal Hyperplasia	Congenital Adrenal Hyperplasia Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency Congenital Lipoid Adrenal Hyperplasia Lipoid Cah Lipoid Adrenal Hyperplasia Adrenal Hyperplasia 1 Cah Clah LCAH Adrenal Hyperplasia I Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism Congenital Adrenal Hyperplasia Lipoid Adrenal Hyperplasia, Congenital Congenital Adrenal Hyperplasia, Lipoid AH1 Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism Adrenal Hyperplasia Congenital Hyperplasia, Adrenal, Lipoid, Congenital Congenital Adrenogenital Disorders Associated With Enzyme Deficiency Congenital Adrenal Cortical Hyperplasia Congenital Adrenal Gland Hyperplasia Congenital Adrenogenital Syndrome Congenital Hyperadrenocorticism Congenital Adrenogenitalism Congenital Female Adrenal Pseudohermaphroditism
Glaucomatocyclitic Crisis	Posner-Schlossman Syndrome Terrien-Viel Syndrome
Achalasia-Addisonianism-Alacrima Syndrome	Allgrove Syndrome Triple-A Syndrome Achalasia-Addisonianism-Alacrimia Syndrome Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder Triple A Syndrome Aaa Syndrome AAAS Glucocorticoid Deficiency With Achalasia Glucocorticoid Deficiency And Achalasia Addisonian-Achalasia Syndrome Hypoadrenalism With Achalasia Alacrima-Achalasia-Addisonianism Aaa Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima Achalasia Addisonianism Alacrimia Syndrome Achalasia Alacrima Syndrome Addisonian Achalasia Syndrome Achalasia-Addisonian Syndrome Achalasia-Alacrima Syndrome 2a Syndrome 3a Syndrome 4a Syndrome Adrenal Insufficiency-Achalasia-Alacrima Syndrome Double A Syndrome Quaternary A Syndrome Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima Allgrove'S Syndrome Adrenal Gland Hypofunction Adrenal Cortical Hypofunction
Ciliary Dyskinesia, Primary, 26	Primary Ciliary Dyskinesia 26 CILD26 Primary Ciliary Dyskinesia 26 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 26, With Or Without Situs Inversus Dyskinesia, Ciliary, Primary, 26
Balanitis
Urethritis	Nonspecific Urethritis Non-Gonococcal Urethritis Nongonococcal Urethritis
Developmental And Epileptic Encephalopathy 53	DEE53 Epileptic Encephalopathy, Early Infantile, 53 Eiee53 Developmental And Epileptic Encephalopathy, 53 Early Infantile Epileptic Encephalopathy 53
Anterior Uveitis	Iridocyclitis Uveitis, Anterior Acute Anterior Uveitis Uveokeratitis Keratouveitis Cyclitis Intraocular Inflammation Kerato-Uveitis Keratoiritis Iritis Uveitis Nos Uveal Inflammation Anterior Chamber Cell
Spondyloarthropathy	Spondylarthropathies Spondarthropathy Spondylarthrosis Spondyloarthropathy, Susceptibility To Spondylarthritis
Reactive Arthritis	Postdysenteric Arthropathy Reiter Disease Pira Reiter Syndrome Reiters Syndrome Arthritis, Reactive Fiessinger Leroy Reiter Syndrome Post-Bacterial Arthropathy Reiter'S Disease Post-Infectious Arthritis Post-Infectious Reactive Arthropathy Reiter'S Syndrome Arthritis Urethritica Fiessinger-Leroy Disease Polyarthritis Enterica Venereal Arthritis Arthritis Reactive Post-Dysenteric Arthropathy Arthritis, Venereal
Optic Papillitis	Papillitis Papilledema
Facial Hemiatrophy	Parry-Romberg Syndrome
Panuveitis	Diffuse Uveitis Total Uveitis Inflammation Of The Whole Uveal Tract
Spondyloarthropathy 1	Ankylosing Spondylitis Spondyloarthropathy, Susceptibility To, 1 SPDA1 Marie-Strumpell Spondylitis Bechterew Syndrome Spa Spondylarthritis Ankylopoietica Reiter Syndrome Ankylosing Spondylitis, Susceptibility To Bekhterev Syndrome Bekhterev'S Disease Marie-Strumpell Disease Axial Spondylarthritis Bechterew Disease Marie-Struempell Disease Spondylitis Ankylopoietica Spondyloarthritis Spondyloarthritis Ankylopoietica Spas Ankylosing Spondylarthritis Psoriatic Arthritis Reactive Arthritis Rheumatoid Spondylitis Spondylitis Ankylosans Spondylitis Ankylosing Spondylitis, Ankylosing Spondylarthropathies Arthritis, Psoriatic Arthritis, Reactive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P10571	GPS1573	Antagonist	99.37%	Unkown
HY-RS07803	LRPAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08638	MRAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08639	MRAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18952	Mrap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22649	Mrap2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25442	Mrap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29163	Mrap2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MRAP	VGNC	VGNC:56121
Rattus norvegicus	MRAP	RGD	RGD:1310648
Mus musculus	MRAP	MGD	MGI:1924287
Macaca mulatta	MRAP	VGNC	VGNC:74729
Bos taurus	MRAP	VGNC	VGNC:56234
Others	MRAP	NCBI