RPL15 - ribosomal protein L15 Gene

Also Known as L15; EC45; DBA12; RPL10; RPLY10; RPYL10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6138

About RPL15

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,916,545-23,924,631 (from NCBI)

This gene has 16 transcripts (splice variants), 160 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 335.5), thyroid (RPKM 183.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric Cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

RPL15 Products (6)

mRNA	Protein	Name
NM_001253379.2	NP_001240308.1	60S ribosomal protein L15 isoform 1
NM_001253380.2	NP_001240309.1	60S ribosomal protein L15 isoform 1
NM_001253382.2	NP_001240311.1	60S ribosomal protein L15 isoform 1
NM_001253383.3	NP_001240312.1	60S ribosomal protein L15 isoform 1
NM_001253384.2	NP_001240313.1	60S ribosomal protein L15 isoform 2
NM_002948.5	NP_002939.2	60S ribosomal protein L15 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21612406	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL15 Protein Structure

Ribosomal_L15e

0
100
204 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L15	large ribosomal subunit protein eL15

RPL15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPL15	P61313	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RPL15	P61313	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RPL15	P61313	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RPL15	P61313	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	RPL15	P61313	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

RPL15 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811340	RPL15 Antibody	WB, IHC-P, FC	Human, Mouse

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 12	DBA12 Rpl15-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 12
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Macrocytic Anemia	Anemia Macrocytic Anemia, Macrocytic Macrocytic Anaemia
Pontocerebellar Hypoplasia, Type 15	PCH15 Pontocerebellar Hypoplasia Type 15 Pontocerebellar Hypoplasia 15 Doid:0112326
Pierre Robin Syndrome	Pierre Robin Sequence Glossoptosis, Micrognathia, And Cleft Palate Pierre Robin Syndrome Skeletal Dysplasia Polydactyly Pierre-Robin Syndrome Isolated Pierre Robin Sequence Isolated Pierre-Robin Syndrome PRBNS Robin Sequence Robin Syndrome Isolated Pierre Robin Syndrome
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities	X-Linked Dyserythropoietic Anemia X-Linked Dyserythropoietic Anemia With Abnormal Platelets And Neutropenia XLANP Anemia, X-Linked, With/Without Neutropenia And/Or Platelet Abnormalities X-Linked Anemia With/Without Neutropenia And/Or Platelet Abnormalities Anemia Without Thrombocytopenia, X-Linked XLAWT Anemia X-Linked With Variable Neutropenia
Retinitis Pigmentosa 10	RP10 Retinitis Pigmentosa-10 Retinitis Pigmentosa, Type 10
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13704	SN-38		99.94%	Unkown
HY-13704S2	SN-38-13C6		/	Unkown
HY-180555	SN38-(PEG)2-Pom-α	Activator	/	Unkown
HY-RS12167	RPL15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPL15	VGNC	VGNC:102831
Mus musculus	RPL15	MGD	MGI:1913730
Canis familiaris	RPL15	VGNC	VGNC:52901
Rattus norvegicus	RPL15	RGD	RGD:621181
Others	RPL15	NCBI