NUP155 - nucleoporin 155 Gene

Also Known as N155; ATFB15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9631

About NUP155

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:37,288,137-37,371,106 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 44.4), bone marrow (RPKM 5.5) and 19 other tissues.

Summary

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

NUP155 Products (3)

mRNA Protein Name
NM_001278312.2 NP_001265241.1 nuclear pore complex protein Nup155 isoform 3
NM_004298.4 NP_004289.1 nuclear pore complex protein Nup155 isoform 2
NM_153485.3 NP_705618.1 nuclear pore complex protein Nup155 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within nuclear envelope organization IDA
IDA: Inferred from direct assay
19070573 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
19070573 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP155 Protein Structure

Nucleoporin_N

Nucleoporin_N: Nup133 N terminal like (78 - 508)

Nucleoporin_C

Nucleoporin_C: Non-repetitive/WGA-negative nucleoporin C-terminal (700 - 1268)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1391 a.a.
Protein Preferred Names Protein Names

nuclear pore complex protein Nup155

  • 155 kDa nucleoporin

NUP155 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NUP155 O75694 LMNA Homo sapiens P02545
Anti Bait CoIP
30488537
Intra
NUP155 O75694 LMNA Homo sapiens P02545
Confocal
30488537
Intra
NUP155 O75694 LMNA Homo sapiens P02545
Pull Down
30488537
Cross: Cross-species interaction Intra: Intraspecies interaction

NUP155 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83378 NUP155 Antibody (YA3123) WB, ICC/IF, FC Human
HY-P83378A NUP155 Antibody (YA3123)(PBS only) WB, ICC/IF Human

Related Diseases

Diseases Alias
Atrial Fibrillation, Familial, 15

  • ATFB15

  • Atrial Fibrillation 15

  • Fibrillation, Atrial, Familial, Type 15
Familial Atrial Fibrillation

  • Atrial Fibrillation, Familial

  • Atfb

  • Atrial Fibrillation Autosomal Dominant

  • Autosomal Dominant Atrial Fibrillation

  • Auricular Fibrillation

  • Atrial Fibrillation

  • Atrial Fibrillation, Familial, 1
Atrial Fibrillation

  • A-Fib

  • Fibrillation, Atrial

  • Af - [Atrial Fibrillation]

  • Rapid Atrial Fibrillation

  • A Fib - [Atrial Fibrillation]
Lethal Congenital Contracture Syndrome 1

  • LCCS1

  • Multiple Contracture Syndrome, Finnish Type

  • Lccs

  • Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures

  • Lethal Congenital Contracture Syndrome Type 1

  • Herva Disease

  • Multiple Contracture Syndrome Finnish Type

  • Contracture Syndrome, Lethal, Congenital, Type 1
Anterior Horn Cell Disease
Lethal Congenital Contracture Syndrome

  • Lccs

  • Lethal Congenital Contracture Syndrome 1
Achalasia-Addisonianism-Alacrima Syndrome

  • Allgrove Syndrome

  • Triple-A Syndrome

  • Achalasia-Addisonianism-Alacrimia Syndrome

  • Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder

  • Triple A Syndrome

  • Aaa Syndrome

  • AAAS

  • Glucocorticoid Deficiency With Achalasia

  • Glucocorticoid Deficiency And Achalasia

  • Addisonian-Achalasia Syndrome

  • Hypoadrenalism With Achalasia

  • Alacrima-Achalasia-Addisonianism

  • Aaa

  • Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima

  • Achalasia Addisonianism Alacrimia Syndrome

  • Achalasia Alacrima Syndrome

  • Addisonian Achalasia Syndrome

  • Achalasia-Addisonian Syndrome

  • Achalasia-Alacrima Syndrome

  • 2a Syndrome

  • 3a Syndrome

  • 4a Syndrome

  • Adrenal Insufficiency-Achalasia-Alacrima Syndrome

  • Double A Syndrome

  • Quaternary A Syndrome

  • Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima

  • Allgrove'S Syndrome

  • Adrenal Gland Hypofunction

  • Adrenal Cortical Hypofunction
Brugada Syndrome

  • Sudden Unexpected Nocturnal Death Syndrome

  • Sudden Unexplained Nocturnal Death Syndrome

  • Bangungut

  • Brugada Type Idiopathic Ventricular Fibrillation

  • Pokkuri Death Syndrome

  • Sunds

  • Idiopathic Ventricular Fibrillation, Brugada Type

  • Sudden Unexplained Death

  • Dream Disease

  • Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

  • Sudden Unexplained Death Syndrome

  • Suds

  • Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-170430 HGC652 Ligand 98.86% Unkown
HY-186250 TRIM21 ligand-1 Ligand / Unkown
HY-RS09686 NUP155 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NUP155 VGNC VGNC:44046
Macaca mulatta NUP155 VGNC VGNC:84456
Bos taurus NUP155 VGNC VGNC:32352
Mus musculus NUP155 MGD MGI:2181182
Felis catus NUP155 VGNC VGNC:102275
Rattus norvegicus NUP155 RGD RGD:621199
Others NUP155 NCBI