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Art. -Nr.: HY-N10624

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Koshidacin B

Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.

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CAS. Nr.: 2925302-01-6
Formel: C₂₈H₄₀N₄O₇
Molecular Weight:544.64

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

Koshidacin B Chemical Structure

CAS. Nr.: 2925302-01-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.89 μM (P. falciparum FCR3 strain), 0.83 μM (P. falciparum K1 strain), 14.7 μM (human MRC-5 cells)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	CC₅₀	14.7 μM Compound: 2	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 36282784]

In Vitro

Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively^[1].
Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC₅₀ value of 14.7 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Koshidacin B (30 mg/kg; i.p.; once daily for 4 d) shows vivo antiplasmodial effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

P. berghei N strain-infected ICR (CD1) mice^[1]
Dosage:

30 mg/kg
Administration:

Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
Result:

Suppressed 41% of malaria parasites.

Chemical Information

CAS. Nr. 2925302-01-6
Molecular Weight 544.64
Formel C₂₈H₄₀N₄O₇
SMILES

OC[C@H](O)C(CCCCC[C@H](NC([C@H]1CCCN1C([C@@H](NC(C(C)(C)N2)=O)CC3=CC=CC=C3)=O)=O)C2=O)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Pochonia boninensis
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Watanabe Y, et al. Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564. J Nat Prod. 2022 Oct 25. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Koshidacin B

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Koshidacin B Related Classifications

HY-N10624 Related Classifications