Lactokinin
Lactokinin is an Endothelin-1 (HY-P0202) release inhibitor and ACE inhibitor, with an ACE IC50 value of 29 μM. Lactokinin binds to bovine β-lactoglobulin variant A to form a non-covalent complex, which delays its hydrolysis by chymotrypsin, as well as by pepsin/chymotrypsin, in vitro. Lactokinin can be used in research related to hypertension.
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- CAS. Nr.: 132160-04-4
- Formel: C37H64N12O8S
- Molecular Weight:837.04
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Lactokinin is bound to purified bovine β-lactoglobulin variant A via non-covalent interactions, and the bound peptide is protected from oxidation and ion adduction during ionization compared to free lactokinin[1].
Lactokinin (0.1-1 mM) inhibits basal and thrombin-stimulated endothelin-1 release from cultured porcine aortic endothelial cells, with 1 mM reducing basal release by 29% and 0.1 mM and 1 mM reducing thrombin-stimulated release by 32% and 43%, respectively[2].
Lactokinin inhibits porcine kidney angiotensin-converting enzyme activity with an IC50 of 29 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 132160-04-4
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Molecular Weight 837.04
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Formel C37H64N12O8S
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SMILES
C[C@H](N)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CCSC)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CC2=CN=CN2)=O)=O)=O)=O
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Sequence
Ala-Leu-Pro-Met-His-Ile-Arg
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Sequence Shortening
ALPMHIR
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[2]. Maes W, et al. Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1 by endothelial cells. Regulatory peptides. 2004 Apr 15;118(1-2):105-9. [Content Brief]
[3]. Pina AS, et al. Studies on the molecular recognition between bioactive peptides and angiotensin-converting enzyme. Journal of molecular recognition : JMR. 2009;22(2):162-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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