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Art. -Nr.: HY-100607S

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Landiolol-d₈

(Synonyms: ONO1101-d₈)

Landiolol-d₈ (ONO1101-d₈) is the deuterium labeled Landiolol (HY-100607). Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β₁ adrenergic receptors. Landiolol specifically blocks cardiac β₁ receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₅H₃₁D₈N₃O₈
Molecular Weight:517.64

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Landiolol-d₈ Chemical Structure

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Bioz

Biologische Aktivität

Beschreibung

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 133242-30-5
Molecular Weight 517.64
Formel C₂₅H₃₁D₈N₃O₈
SMILES

O=C(OC[C@H]1OC(C)(C)OC1)CCC2=CC=C(OC[C@@H](O)CNCCNC(N3C([2H])([2H])C([2H])([2H])OC([2H])([2H])C3([2H])[2H])=O)C=C2
Synonyms

ONO1101-d₈
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.