Loxicodegol
Loxicodegol (Oxycodegol) is a first-in-class, long-acting, orally active, and selective mu-opioid agonist with structural properties that reduce its rate of entry across the blood-brain barrier compared with traditional mu-opioid agonists.
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- CAS. Nr.: 1211231-76-3
- Formel: C31H49NO10
- Molecular Weight:595.72
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1211231-76-3
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Molecular Weight 595.72
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Formel C31H49NO10
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SMILES
O[C@@]1(CC[C@H](OCCOCCOCCOCCOCCOCCOC)[C@]2([H])OC3=C4OC)[C@]52C3=C(C=C4)C[C@@]1([H])N(C)CC5
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Synonyms
Oxycodegol; NKTR-181
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Miyazaki T, et al. NKTR-181: A Novel Mu-Opioid Analgesic with Inherently Low Abuse Potential. J Pharmacol Exp Ther. 2017;363(1):104-113. [Content Brief]
[2]. Gudin J, et al. Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS). Pain Med. 2020;21(7):1347-1356. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Loxicodegol Related Classifications
HY-109064 Related Classifications
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