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Art. -Nr.: HY-155149

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MAT2A-IN-12

MAT2A Allosteric inhibitor 2 is a potent and selective MAT2A allosteric inhibitor with an IC₅₀ of 5 nM. MAT2A Allosteric inhibitor 2 shows nanomolar activity (IC₅₀=5 μM) in the the proliferation assay (MTAP^-/- cell line).

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CAS. Nr.: 631897-75-1
Formel: C₂₀H₁₇NO₃
Molecular Weight:319.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

MAT2A-IN-12 Chemical Structure

CAS. Nr.: 631897-75-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4.957 μM Compound: 17; STL235627	Antiproliferative activity against MTAP-/- isogenic variant of human HCT-116 cells assessed as inhibition of cell growth by proliferation assay Antiproliferative activity against MTAP-/- isogenic variant of human HCT-116 cells assessed as inhibition of cell growth by proliferation assay	[PMID: 37591318]
HCT-116	IC₅₀	9.23 μM Compound: 17; STL235627	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by proliferation assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by proliferation assay	[PMID: 37591318]

Chemical Information

CAS. Nr. 631897-75-1
Molecular Weight 319.35
Formel C₂₀H₁₇NO₃
SMILES

CC1=CC(OC2=C3C=C(OC)C=C2)=C3C(C4=CC=C(C)C=C4)=[N+]1[O-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tuomo Kalliokoski, et al. Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening. Bioorg Med Chem Lett . 2023 Oct 1;94:129450 [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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