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Art. -Nr.: HY-137156

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NB-64

NB-64 is an orally active HIV-1 inhibitor. NB-64 is promising for research of HIV infections.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 53242-68-5
Formel: C₁₁H₈ClNO₂
Molecular Weight:221.64

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NB-64 Chemical Structure

CAS. Nr.: 53242-68-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NB-64 is an orally active HIV-1 inhibitor. NB-64 is promising for research of HIV infections^[1].

IC₅₀ & Target

HIV-1

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	CC₅₀	>4000 μM Compound: 15ii, NB-64	Toxicity against human MT2 cells Toxicity against human MT2 cells	[PMID: 26116177]
MT2	CC₅₀	335.7 μM Compound: 1, NB-64	Cytotoxicity against human MT2 cells after 4 days using XTT assay Cytotoxicity against human MT2 cells after 4 days using XTT assay	[PMID: 22014749]
MT2	CC₅₀	335.72 μM Compound: A1, NB-64	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19053778]
MT2	EC₅₀	2.39 μM Compound: A1, NB-64	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19053778]
MT2	EC₅₀	2.4 μM Compound: 1, NB-64	Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA	[PMID: 22014749]
MT2	EC₅₀	29.92 μM Compound: 15ii, NB-64	Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells	[PMID: 26116177]
U373-MAGI	CC₅₀	>4000 μM Compound: 15ii, NB-64	Toxicity against human U373-MAGI-CXCR4-CEM cells Toxicity against human U373-MAGI-CXCR4-CEM cells	[PMID: 26116177]
U-87MG ATCC	CC₅₀	>4000 μM Compound: 15ii, NB-64	Toxicity against human U87-T4-CXCR4 cells Toxicity against human U87-T4-CXCR4 cells	[PMID: 26116177]

Chemical Information

CAS. Nr. 53242-68-5
Molecular Weight 221.64
Formel C₁₁H₈ClNO₂
SMILES

O=C(C1=CC(N2C=CC=C2)=CC=C1Cl)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jiang S, et al. N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion. Antimicrob Agents Chemother. 2004 Nov;48(11):4349-59. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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NB-64

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

NB-64 Related Classifications

HY-137156 Related Classifications