country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-P11624

Copy Link Print Information

PP-60

PP-60 is an apoptosis inducer. PP-60 inhibits the proliferation of cancer cells and induces cancer cell apoptosis. PP-60 exerts anti-tumor effects in nude mouse liver tumor models. PP-60 is applicable to research related to cancers such as liver cancer, lung cancer, and prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₄₂H₂₅₂N₃₆O₄₀
Molecular Weight:3103.74

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

PP-60 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

PP-60 (24 h) exhibits potent antiproliferative activity against HepG2, A549 and PC-3 cells, with IC₅₀ values of 1.73, 2.15 and 2.69 μM^[1].
PP-60 (2 μM; 2-4 h) exhibits excellent cellular uptake capacity^[1].
PP-60 (0-5 μM) inhibits G2 phase cell cycle progression in HepG2 cells in a dose-dependent manner, and the percentage of cells in the G2 phase reaches approximately 35% at a concentration of 5 μM^[1].
PP-60 (0-5 μM, 6 h) induces apoptosis in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HepG2 cells
Concentration:

2 μM
Incubation Time:

2, 4 h
Result:

Increased FITC fluorescence signal intensity indicates a stronger cellular uptake capacity.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

0, 1, 2, 5 μM
Incubation Time:

6 h
Result:

Induced apoptosis, at a concentration of 5 μM, the apoptosis rate is approximately 80%.

In Vivo

PP-60 (0.5 mg per mouse; intratumoral injection; administered on days 1, 6, and 15) exhibits potent antitumor activity in the HepG2 xenograft nude mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude mice (female; HepG2 (2 × 10⁶ cells/mouse) xenograft model)^[1]
Dosage:

0.5 mg per mouse
Administration:

intratumoral injection; on day 1, 6, and 15
Result:

Exhibited potent antitumor activity.
Reduced tumor volume; decreased tumor weight; showed the highest caspase 3 positive staining; reduced Ki67 positive cells to the lowest level; induced significant tumor cell apoptosis.

Chemical Information

Molecular Weight 3103.74
Formel C₁₄₂H₂₅₂N₃₆O₄₀
Sequence

Ac-{Arg(β-Glu(1→4)-α-Glu)}-Leu-{(S)-2-(4-pentenyl)alanine}-Lys-Asp-Lys-{(S)-2-(4-pentenyl)alanine}-Lys-Gly-Ile-Gly-Lys-Leu-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-{(S)-2-(4-pentenyl)alanine}--Lys-Thr-Leu-{(S)-2-(4-pentenyl)alanine}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
Sequence Shortening

Ac-{Arg(β-Glu(1→4)-α-Glu)}-L-{S5}-KDK-{S5}-KGIGKLAGKAALGA-{S5}-KTL-{S5}-NH2 (RCM bridge: {S5}3-{S5}7, {S5}22-{S5}26)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Fu Y, et al. Design, Synthesis, and Biological Evaluation of Arginine N-Glycosylation Stapled Peptides with Potent Antitumor Activity In Vivo. J Med Chem. 2025;68(19):20435-20448. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen