Gastrin
Gastrin is the principal hormonal stimulant of gastric acid secretion, produced by G cells of the gastric antrum and duodenum as a prohormone processed into amidated gastrin-17 and gastrin-34. Released by peptides, amino acids and gastric distension, gastrin binds the cholecystokinin B/gastrin receptor on enterochromaffin-like (ECL) cells and parietal cells, stimulating histamine release and acid output while also exerting trophic effects on the oxyntic mucosa. Gastrin release is restrained by acid via somatostatin; chronic proton pump inhibitor use therefore causes hypergastrinemia, and gastrinoma-driven Zollinger-Ellison syndrome produces refractory ulcers. Elevated progastrin and amidated gastrin have trophic roles in colorectal and gastric carcinogenesis, making the gastrin pathway a drug development focus.
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Gastrin Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
