TOPK
TOPK, the T-LAK cell-originated protein kinase encoded by PBK, resembles a MAP kinase kinase in domain architecture yet operates outside the canonical three-tier cascades. It is kept inactive in interphase and is phosphorylated by CDK1-cyclin B at Thr9 as cells enter mitosis, after which it supports spindle function and cytokinesis. TOPK is highly expressed in testis and in activated lymphoid cells and is overexpressed in a broad range of tumors, where it contributes to proliferation, survival and resistance to oxidative stress through interactions with peroxiredoxins and other partners. The clinical candidate OTS514 targets TOPK and causes mitotic arrest and tumor regression in preclinical models.
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TOPK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
