Hypoxanthine is involved in promoting the activation of mouse primordial follicles†

  • Biol Reprod. 2026 Jan 12:ioag007. doi: 10.1093/biolre/ioag007.
Ying Wei  1 ,  Weiyong Wang  1 ,  Huiyu Liu  1 ,  Tiantian Hao  1 ,  Yan-Li Sun  1 ,  Shuang Liu  1 ,  Hongwei Wei  1 ,  Wenbo Zhang  1 ,  Xiaodan Zhang  1 ,  Meijia Zhang  1
Affiliations
  • 1. The Innovation Centre of Ministry of Education for Development and Diseases, The Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
PMID: 41524735 DOI: 10.1093/biolre/ioag007
Abstract

In each wave, only a small portion of primordial follicles are selectively activated into the growing follicular pool, and the majority of primordial follicles remain in a relatively quiescent state. Hypoxanthine is present in the follicular fluid with high concentrations and inhibits phosphodiesterase (PDE) activity. $$ contribute to the promotion of the cyclic activation of primordial follicles.

Keywords
Hypoxanthine; Oocyte; PI3K/Akt pathway; Primordial follicle activation; cAMP.
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