Vitexilactone
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Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 97.67%
- CAS. Nr.: 61263-49-8
- Formel: C22H34O5
- Molecular Weight:378.50
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
| HCT-116 | GI50 |
>5000 ng/mL
Compound: 13
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 11975496] |
| HCT-116 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
| HL-60 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
| PC-12 | GI50 |
>5000 ng/mL
Compound: 13
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Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against rat PC12 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 11975496] |
| RAW264.7 | IC50 |
42.5 μM
Compound: 1
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
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[PMID: 24035341] |
| ZR-75-30 | IC50 |
<5 μg/mL
Compound: Vitexilactone
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Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay
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[PMID: 23327905] |
Vitexilactone shows significant antimicrobial activity towards E. coli with an MIC value ＞90 μg/mL[1]. Vitexilactone (0-100 μg/mL; 17-24 h) inhibits cell proliferation of mammalian cancer cells[2]. Vitexilactone (25-100 μg/mL; 17 h) induces cell apoptosis at higher concentrations, while inhibits the cell cycle G0/G1 phase at lower concentrations of tsFT210 and K562 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:tsFT210 and K562 cells lines
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Concentration:0-100 μg/mL
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Incubation Time:17-24 hours
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Result:Inhibited cell proliferation of mammalian cancer cells with IC50 values of 86.9 and 57.9 μg/mL for tsFT210 and K562 cells, respectively.
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Cell Line:tsFT210 and K562 cell lines
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Concentration:25-100 μg/mL
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Incubation Time:17 hours
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Result:Induced cell apoptosis of tsFT210 with a MIC value of 25 μg/mL.
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Cell Line:tsFT210 and K562 cell lines
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Concentration:25-100 μg/mL
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Incubation Time:17 hours
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Result:Inhibited G0/G1 phase of cell cycle with the dose ranges of 50-6.25 μg/mL in tsFT210 cells.
Chemical Information
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CAS. Nr. 61263-49-8
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Appearance Solid
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Molecular Weight 378.50
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Formel C22H34O5
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Color White to off-white
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SMILES
O=C1OCC(CC[C@@]2(O)[C@H](C)C[C@@H](OC(C)=O)[C@@]3([H])C(C)(C)CCC[C@]23C)=C1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Sichaem J, et al. A new labdane-type diterpenoid from the leaves of Vitex negundo L. Nat Prod Res. 2021 Jul;35(14):2329-2334. [Content Brief]
[2]. Li WX, et al. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L. J Asian Nat Prod Res. 2005 Apr;7(2):95-105. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Vitexilactone Related Classifications
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