Labdane-type diterpenoids from the fruits of Vitex trifolia

  • J Nat Prod. 2013 Feb 22;76(2):287-91. doi: 10.1021/np300679x.
Cheng-Jian Zheng  1 ,  Jian-Yong Zhu ,  Wu Yu ,  Xue-Qin Ma ,  Khalid Rahman ,  Lu-Ping Qin
Affiliations
  • 1. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
PMID: 23327905 DOI: 10.1021/np300679x
Abstract

Seven new labdane-type Diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human Cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg/mL).