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Art. -Nr.: HY-184560

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VL285-PEG3-I

VL285-PEG3-I (Compound 6) is an E3 ligase ligand-linker conjugate. VL285-PEG3-I is used for the synthesis of PROTAC SJFδ (HY-114405).

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CAS. Nr.: 2254609-31-7
Formel: C₃₅H₄₃IN₄O₇S
Molecular Weight:790.71

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

VL285-PEG3-I Chemical Structure

CAS. Nr.: 2254609-31-7

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

VL285-PEG3-I (Compound 6) is an E3 ligase ligand-linker conjugate. VL285-PEG3-I is used for the synthesis of PROTAC SJFδ (HY-114405)^[1].

Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen :

In Vitro

E3 ligase ligand-linker conjugates are components of proteolysis-targeting chimeras (PROTACs). They consist of a ligand for an E3 ubiquitin ligase and a linker, and when connected to a ligand for a target protein (e.g., JQ1 binds to BRD4, Molibresib binds to BET proteins), they can be used to construct PROTACs that induce ubiquitination and degradation of the target protein.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2254609-31-7
Molecular Weight 790.71
Formel C₃₅H₄₃IN₄O₇S
SMILES

ICCOCCOCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4C(C5=CC=CC=C5C4)=O)C(C)C)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Smith BE, et al.. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nature communications. 2019 Jan 10;10(1):131. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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VL285-PEG3-I

Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

VL285-PEG3-I Related Classifications

HY-184560 Related Classifications