Zgwatinib
Zgwatinib (SOMG-833) is a potent, selective, and ATP-competitive c-MET inhibitor, with an IC50 of 0.93 nM against c-MET, over 10,000-fold more potent compared with 19 tyrosine kinases (including c-MET family members and highly homologous kinases). Zgwatinib potently inhibits c-MET-driven cell proliferation. Zgwatinib as a potential candidate agent for c-MET-driven human cancers research.
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- CAS. Nr.: 1268264-10-3
- Formel: C22H22F3N5O2
- Molecular Weight:445.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
IC50: 0.93 nM (c-MET)[1]
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
0.049 μM
Compound: 1
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Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay
Displacement of [3H]dofetilide from human ERG expressed in CHO cells after 30 mins by FluxOR thallium assay
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10.1039/C2MD20192E |
Chemical Information
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CAS. Nr. 1268264-10-3
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Molecular Weight 445.44
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Formel C22H22F3N5O2
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SMILES
O=[N+]([O-])C1=CC(CNC2=C3C=C(C=NC3=CC(C(F)(F)F)=C2)N4CCN(CC4)C)=CC=C1
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Synonyms
SOMG-833
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Zgwatinib Related Classifications
HY-124267 Related Classifications
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