Zinterol
Based on 1 publication(s) in Google Scholar
Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM.
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- CAS. Nr.: 37000-20-7
- Formel: C19H26N2O4S
- Molecular Weight:378.49
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Zinterol
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Biologische Aktivität
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β adrenergic receptor |
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
0.054 nM
Compound: Zinterol
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Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
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[PMID: 20804199] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:In New Zealand White HF rabbits of either sex[3]
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Dosage:1.0 or 2.5 μg/kg
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Administration:Intravenous bolus administration; over 5 seconds
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Result:2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
Chemical Information
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CAS. Nr. 37000-20-7
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Appearance Solid
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Molecular Weight 378.49
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Formel C19H26N2O4S
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Color White to off-white
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SMILES
CS(=O)(NC1=CC(C(O)CNC(C)(C)CC2=CC=CC=C2)=CC=C1O)=O
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Synonyms
MJ 9184
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85. [Content Brief]
[2]. Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61. [Content Brief]
[3]. Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Zinterol Related Classifications
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