EPHB2 - EPH receptor B2 Gene

Also Known as DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; BDPLT22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2048

About EPHB2

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,710,838-22,921,500 (from NCBI)

This gene has 7 transcripts (splice variants), 288 orthologues, 53 paralogues and is associated with 3 phenotypes. Broad expression in colon (RPKM 7.3), small intestine (RPKM 5.2) and 17 other tissues.

Summary

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called Ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph Receptors called EphB. Proteins of this subgroup are distinguished from Other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain Cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

EPHB2 Products (4)

mRNA	Protein	Name
NM_001309192.2	NP_001296121.1	ephrin type-B receptor 2 isoform 3 precursor
NM_001309193.2	NP_001296122.1	ephrin type-B receptor 2 isoform 4 precursor
NM_004442.7	NP_004433.2	ephrin type-B receptor 2 isoform 2 precursor
NM_017449.5	NP_059145.2	ephrin type-B receptor 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IDA IDA: Inferred from direct assay	33280498	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17255949	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell activation	IMP IMP: Inferred from mutant phenotype	24803541	GOA
involved in negative regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	23835497	GOA
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	24803541	GOA
involved in positive regulation of cell migration	IGI IGI: Inferred from genetic interaction	23204229	GOA
involved in positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	24803541	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	24803541	GOA
acts upstream of positive effect regulation of autophagosome assembly	IDA IDA: Inferred from direct assay	33280498	GOA
involved in regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	30213874	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHB2 Protein Structure

Ephrin_lbd

Ephrin_rec_like

fn3

EphA2_TM

Pkinase_Tyr

SAM_1

0
200
400
600
800
1000
1055 a.a.

Protein Preferred Names	Protein Names
ephrin type-B receptor 2	EPH-like kinase 5

EPHB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EPHB2	P29323	NUP153	Homo sapiens	P49790	Pull Down	17255949
Intra	EPHB2	P29323	EPHA4	Homo sapiens	P54764	BioID	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70790	EphB2 Protein, Human (HEK293, Fc)	Q6NVW1 (V19-S482)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73000	EphB2 Protein, Human (Active, sf9, His-GST)	P29323-3 (G570-V987)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73001	EphB2 Protein, Human (HEK293, His-Fc)	P29323-1/NP_059145.2 (V19-L543)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75237	EphB2 Protein, Human (HEK293, His)	P29323-1 (V19-L543)	≥ 95%, as determined by reducing SDS-PAGE.

EPHB2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84243	EphB2 Antibody (YA3940)	ICC/IF, ELISA	Human
HY-P84243A	EphB2 Antibody (YA3940)(PBS only)	ICC/IF, ELISA	Human
HY-P85146	EphB2 Antibody (YA4838)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Bleeding Disorder, Platelet-Type, 22	BDPLT22
Prostate Cancer/Brain Cancer Susceptibility	Pcbc Capb Prostate Cancer/Brain Cancer Susceptibility, Somatic
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Small Cell Carcinoma	Small Cell Carcinoma, Intermediate Cell Intermediate Cell Small Cell Carcinoma Small Cell Carcinoma - Intermediate Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Craniofrontonasal Syndrome	Craniofrontonasal Dysplasia CFNS Cfnd Craniofrontonasal Dysostosis Craniofrontonasal Dystosis Dysplasia, Craniofrontonasal
Supratentorial Ependymoma
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18833	ALW-II-49-7	Inhibitor	99.97%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-170517	PKMYT1-IN-8	Inhibitor	99.31%	Unkown
HY-179572	STA-013		99.18%	Unkown
HY-146375	UniPR505	Antagonist	99.68%	Unkown
HY-157019	UniPR1447	Antagonist	99.46%	Unkown
HY-P10630	Pep63	Inhibitor	/	Unkown
HY-RS04434	EPHB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17199	Ephb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23651	Ephb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24537	Ephb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990405	Anti-EphB2 Antibody	Inhibitor	99.36%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EPHB2	RGD	RGD:1564232
Bos taurus	EPHB2	VGNC	VGNC:54424
Mus musculus	EPHB2	MGD	MGI:99611
Canis familiaris	EPHB2	VGNC	VGNC:40411
Felis catus	EPHB2	VGNC	VGNC:80196
Macaca mulatta	EPHB2	VGNC	VGNC:99906
Others	EPHB2	NCBI