TRRAP - transformation/transcription domain associated protein Gene

Also Known as Tra1; TR-AP; DEDDFA; DFNA75; PAF400; STAF40; PAF350/400

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8295

About TRRAP

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:98,878,532-99,013,241 (from NCBI)

This gene has 14 transcripts (splice variants), 242 orthologues, 5 paralogues and is associated with 118 phenotypes. Ubiquitous expression in testis (RPKM 10.2), ovary (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many Histone Acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of Cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

TRRAP Products (3)

mRNA	Protein	Name
NM_001244580.2	NP_001231509.1	transformation/transcription domain-associated protein isoform 1
NM_001375524.1	NP_001362453.1	transformation/transcription domain-associated protein isoform 3
NM_003496.4	NP_003487.1	transformation/transcription domain-associated protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9708738	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	11418595	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	27153538	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27153538	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NuA4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	10966108	GOA
part of SAGA complex	IDA IDA: Inferred from direct assay	11564863	GOA
part of Swr1 complex	IDA IDA: Inferred from direct assay	24463511	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27153538	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9708738	GOA
part of transcription factor TFTC complex	IDA IDA: Inferred from direct assay	10373431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRRAP Protein Structure

FAT

PI3_PI4_kinase

0
600
1200
1800
2400
3000
3600
3859 a.a.

Protein Preferred Names	Protein Names
transformation/transcription domain-associated protein	350/400 kDa PCAF-associated factor

TRRAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRRAP	Q9Y4A5	MYC	Homo sapiens	P01106	Anti Tag CoIP	35271311
Intra	TRRAP	Q9Y4A5	MYC	Homo sapiens	P01106	CoIP	9708738
Intra	TRRAP	Q9Y4A5	ATXN7	Homo sapiens	O15265	Anti Tag CoIP	35271311
Intra	TRRAP	Q9Y4A5	ATXN7	Homo sapiens	O15265	Anti Bait CoIP	15115762

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental Delay With Or Without Dysmorphic Facies And Autism	DEDDFA
Deafness, Autosomal Dominant 75	DFNA75 Deafness, Autosomal Dominant, 75
Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna	Autosomal Dominant Isolated Neurosensory Deafness Type Dfna Autosomal Dominant Isolated Neurosensory Hearing Loss Type Dfna Autosomal Dominant Isolated Sensorineural Deafness Type Dfna Autosomal Dominant Isolated Sensorineural Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Deafness Type Dfna Autosomal Dominant Non-Syndromic Neurosensory Hearing Loss Type Dfna Autosomal Dominant Non-Syndromic Sensorineural Hearing Loss Type Dfna
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Hemangioma Of Spleen	Splenic Hemangioma
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS22883	Trrap Mouse Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRRAP	VGNC	VGNC:66601
Bos taurus	TRRAP	VGNC	VGNC:36403
Mus musculus	TRRAP	MGD	MGI:2153272
Macaca mulatta	TRRAP	VGNC	VGNC:78657
Rattus norvegicus	TRRAP	RGD	RGD:1305446
Canis familiaris	TRRAP	VGNC	VGNC:47887
Others	TRRAP	NCBI