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Cat. No.: HY-P2045

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RA-VII

RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma.

For research use only. We do not sell to patients.

CAS No.: 86229-97-2
Formula: C₄₁H₅₀N₆O₉
Molecular Weight:770.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RA-VII Chemical Structure

CAS No.: 86229-97-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
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Classifications
Bioz

Biological Activity

Description

RA-VII is an antitumor agent that exhibits significant activity against L1210, B-16 melanoma, Lewis lung carcinoma, Colon 38 and Ehrlich carcinoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.0033 μg/mL Compound: 1, RA-VII	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 24268554]
HL-60	IC₅₀	0.0025 μg/mL Compound: 1, RA-VII	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 24268554]
KB	IC₅₀	0.0023 μg/mL Compound: 1 (RA-VII)	Cytotoxicity in human epidermoid carcinoma of the nasopharynx(KB) cells Cytotoxicity in human epidermoid carcinoma of the nasopharynx(KB) cells	10.1016/S0960-894X(01)80580-1
L1210	IC₅₀	0.002 μg/mL Compound: 1	In vitro cytotoxicity against L1210 (murine leukemia) cells. In vitro cytotoxicity against L1210 (murine leukemia) cells.	10.1016/S0960-894X(01)80815-5
P388	IC₅₀	0.0013 μg/mL Compound: 1 (RA-VII)	Cytotoxicity in murine lymphocytic leukemia (P388) cells Cytotoxicity in murine lymphocytic leukemia (P388) cells	10.1016/S0960-894X(01)80580-1
P388	IC₅₀	0.0015 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18993061]
P388	IC₅₀	0.0022 μM Compound: 1, RA-VII	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 21382716]
P388	IC₅₀	0.003 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 18078747]
P388	IC₅₀	0.0043 μg/mL Compound: 1, RA-VII	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 22460024]

Chemical Information

CAS No. 86229-97-2
Molecular Weight 770.87
Formula C₄₁H₅₀N₆O₉
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Itokawa H, et al. Isolation and antitumor activity of cyclic hexapeptides isolated from Rubiae radix. Chem Pharm Bull (Tokyo). 1984 Jan;32(1):284-90. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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