A novel bicyclic hexapeptide, RA-XVIII, from Rubia cordifolia: structure, semi-synthesis, and cytotoxicity

  • Bioorg Med Chem Lett. 2008 Jan 15;18(2):808-11. doi: 10.1016/j.bmcl.2007.11.030.
Ji-Ean Lee  1 ,  Yukio Hitotsuyanagi ,  Ik-Hwi Kim ,  Tomoyo Hasuda ,  Koichi Takeya
Affiliations
  • 1. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 18078747 DOI: 10.1016/j.bmcl.2007.11.030
Abstract

A new bicyclic peptide of RA-series, RA-XVIII (3), was isolated from the roots of Rubia cordifolia L. Its structure was established to be a hydroxylated derivative of RA-VII by the semi-synthesis of 3 from deoxybouvardin, and its cytotoxicity against P-388 cells was 0.012 microg/mL.