AD 0261
AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
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- CAS No.: 145600-69-7
- Formule: C27H31F2N3O
- Masse moléculaire:451.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC50=0.022 μM) and superoxide anions (IC50= 0.9-4.0 μM). AD 0261 inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity, the IC50 value being around 1.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 145600-69-7
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Masse moléculaire 451.55
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Formule C27H31F2N3O
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SMILES
OC1=CC=C(C)C=C1NCCCN2CCN(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
For measurement of [3H]TdR incorporation, cells are incubated for 16 h and additional (6 h) incubation is carried out in the presence of [3H]TdR (0.5 μCi/well). [3H]TdR incorporation is evaluated in a liquid scintillation counter. IL-2 release from lymphocytes is estimated after 20 h incubation by enzyme immunoassay using the commercially available kits. IL-2 receptor expression is quantitated by flow-cytometry using an FITC-labelled monoclonal antibody which recognizes achain of IL-2 receptor complex. Cell viability is determined by either trypan blue exclusion test or propidium iodide staining.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AD 0261 Related Classifications
HY-U00005 Related Classifications
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