Acetobixan
Acetobixan is an inhibitor of Cellulose Synthase A6 (CESA6). Acetobixan inhibits cellulose components of Pythium insidiosum cell walls. Acetobixan can be used for the research of Pythium insidiosum keratitis.
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- CAS No.: 380201-24-1
- Formule: C16H17NO2S
- Masse moléculaire:287.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
Acetobixan disrupts cellulose biosynthesis in plant cells by dissociating YFP-tagged CESA6 complexes from the plasma membrane[1].
Acetobixan (1-10 μM; 7 days) reduces cellulose content in a concentration-dependent manner in dark-grown wild-type Arabidopsis thaliana seedlings, with significant reductions observed at 5 μM and 10 μM[2].
Acetobixan (50 μM; 1 h) induces relocalization of YFP-CesA6 from the plasma membrane to cytoplasmic vesicles without disrupting cortical microtubules in transgenic Arabidopsis thaliana seedlings[2].
Acetobixan (1-20 μM; 7 days) inhibits root growth in wild-type, ixr1-2, ixr2-1, and aegeus/ags Arabidopsis thaliana seedlings equally, shows concentration-dependent hypocotyl growth inhibition in dark-grown wild-type seedlings[2].
Acetobixan (1 μM) inhibits cellulose biosynthesis in etiolated Arabidopsis thaliana seedlings, reduces plasma membrane-localized cellulose synthase complexes, and inhibits hypocotyl elongation[3].
Acetobixan potently inhibits cellulose biosynthesis in wild-type Arabidopsis thaliana seedlings, inducing severe radial swelling without disrupting cortical microtubule dynamics, and does not exhibit cross-resistance with isoxaben-resistant Arabidopsis thaliana mutants[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 380201-24-1
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Masse moléculaire 287.38
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Formule C16H17NO2S
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SMILES
O=C(CSC1=CC=CC=C1)NCC2=CC=CC=C2OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gurnani B, et al. Breaking-Down Barriers: Proposal of Using Cellulose Biosynthesis Inhibitors and Cellulase Enzyme as a Novel Treatment Modality for Vision Threatening Pythium Insidiosum Keratitis. Clin Ophthalmol. 2024 Mar 11;18:765-776. [Content Brief]
[2]. Xia Y, et al. Acetobixan, an inhibitor of cellulose synthesis identified by microbial bioprospecting. PLoS One. 2014 Apr 18;9(4):e95245. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)