Aminopyridine 2
Aminopyridine 2 is an irreversible, selective, and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 0.16 μM and a Ki of 24 μM against human MPO. Aminopyridine 2 is applicable to research on chronic inflammatory diseases.
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- CAS No.: 2411643-58-6
- Formule: C13H13BrN4O
- Masse moléculaire:321.18
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Activité biologique
Description
In Vitro
Aminopyridine 2 (2 h) inhibits the activity of human MPO in plasma, with an apparent IC50 of 1.9 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Parmacokinetics
In Vivo
Aminopyridine 2 (~50-200 mg/kg; mixed with diet for 14 days) dose-dependently inhibits MPO activity in a mouse peritonitis model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 8 weeks old)[1]
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Dosage:2.5 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
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Administration:i.g.; single dose
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Result:Reduced residual plasma MPO activity by 24% at 2.5 mg/kg, 62% at 25 mg/kg, 74% at 50 mg/kg, and 86% at 100 mg/kg, measured 5 hours post-dose.
Caused dose-dependent inhibition of 3-chlorotyrosine accumulation in peritoneal exudate.
Achieved an apparent in vivo IC50 of 1.4 μM for inhibition of plasma MPO activity.
Chemical Information
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CAS No. 2411643-58-6
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Masse moléculaire 321.18
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Formule C13H13BrN4O
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SMILES
O=C(NC1=CC=C(Br)C=C1)NCC2=CN=C(N)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aminopyridine 2 Related Classifications
HY-126017 Related Classifications
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