Antitumor agent-23
Antitumor agent-23 is a potent anti-cancer agent with GI50s of 38, 48, 5, 27, 80, and 28 nM for lymphoma cell line GRANTA-519, KARPAS-422, KARPAS-299, RAMOS, DAUDI, and RAJI, respectively. Antitumoral activity.
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- CAS No.: 2355185-12-3
- Formule: C28H50N4O4
- Masse moléculaire:506.72
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
In Vitro
Antitumor agent-23 (0.001-100 μM; 5 days) inhibits lymphoma cells proliferation[1].
Antitumor agent-23 (2-70 nM; 72 hours) induces p53 protein expression and p53 lysine 382 acetylation (K382Ac-p53) in HPV-positive cervical cancer cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:Lymphoma cell line GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI
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Concentration:0.001, 0.01, 0.1, 1, 10, 100 μM
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Incubation Time:5 days
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Result:The GI50s of 38, 48, 5, 27, 80, 28 nM for GRANTA-519, KARPAS-422,KARPAS-299, RAMOS, DAUDI, RAJI cells, respectively.
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Cell Line:HPV16-positive cervical cancer cell line (CaSki cell)
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Concentration:2, 7, 20, and 70 nM
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Incubation Time:72 hours
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Result:Induction of p53 protein above baseline was evident at 7 nM already, acetylation of p53 lysine 382 was detectable at 20 nM.
Chemical Information
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CAS No. 2355185-12-3
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Masse moléculaire 506.72
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Formule C28H50N4O4
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SMILES
C[C@H]1C[C@](OC[C@@H]2CN3CCCC3)(OC2)CCN1C([C@@H](N(CCN[C@H]4CC(C)C)C4=O)CC(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-23 Related Classifications
HY-136342 Related Classifications
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