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Cat. No.: HY-190159

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AZ-008

AZ-008 is a PPI-stabilizing molecular glue that acts as a 14-3-3σ/p53^T387 protein-protein interaction stabilizer. AZ-008 has potential for cancer research.

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CAS No.: 2488429-67-8
Formule: C₁₅H₂₀N₄O₂S
Masse moléculaire:320.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

AZ-008 Chemical Structure

CAS No.: 2488429-67-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

AZ-008 is a PPI-stabilizing molecular glue that acts as a 14-3-3σ/p53^T387 protein-protein interaction stabilizer. AZ-008 has potential for cancer research^[1].

IC₅₀ & Target

^[1]

14-3-3σ

Voir tous les produits spécifiques à Isoform 14-3-3 Protein :

In Vitro

AZ-008 (500 µM) binds to 14-3-3σ by WaterLOGSY NMR both in the presence and absence of p53pT387^[1].
AZ-008 (2000 µM) binds the same 14-3-3σ pocket in the presence or absence of p53pT387 and increases the amount of 14-3-3σ/p53pT387 complex in solution as shown by TROSY-HSQC NMR^[1].
AZ-008 (1 mM; 1 h) increases the binding of 14-3-3σ to the fluorescently labeled p53pT387 peptide in FP, consistent with a weak stabilizing effect^[1].
AZ-008 (1 mM) stabilizes the binding of 14-3-3σ to the immobilized p53pT387 peptide in SPR, consistent with a weak stabilizing effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2488429-67-8
Masse moléculaire 320.41
Formule C₁₅H₂₀N₄O₂S
SMILES

CC(OC1=C2C(C=C(C(N)=N)S2)=C(C(NCCN)=O)C=C1)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Guillory X, et al. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry. 2020 Jul 09;63(13):6694-6707.

Calculators

Calculateur de molarité

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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AZ-008

Voir tous les produits spécifiques à Isoform 14-3-3 Protein