Cimpuciclib tosylate
Based on 1 Customer Validation
Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
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- Pureté: 99.65%
- CAS No.: 2408872-84-2
- Formule: C37H43FN8O4S
- Masse moléculaire:714.85
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CDK4 0.49 nM (IC50) |
CDK6 9.56 nM (IC50) |
Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Colo205 cells
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Concentration:0-500 nM approximately
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Incubation Time:6 days
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Result:Inhibited cell proliferation with an IC50 value of 141.2 nM.
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Colo205 tumor-bearing mice[1]
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Dosage:50 mg/kg, twice a week
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Administration:Oral gavage
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Result:Inhibited tumor growth by 93.63%
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Animal Model:Rats, colo205 tumor-bearing mice[1]
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Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
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Administration:Oral administration
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Result:Pharmacokinetic profile of Cimpuciclib (example 63).
dose Cmax (ng/mL) Tmax (h) AUC0-24 (ng/mL•h) t1/2 (h) 5 mg/kg (rats) 559.7 6 5414 2.4 50 mg/kg (mice) 7960 1 136782 14.8
Chemical Information
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CAS No. 2408872-84-2
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Appearance Solid
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Masse moléculaire 714.85
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Formule C37H43FN8O4S
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Color White to off-white
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SMILES
O=C(N1CCC(CC1)NC2CC2)C3=CC=C(NC4=NC(C5=CC6=C(N=C(C)N6C(C)C)C=C5)=C(F)C=N4)N=C3C.O=S(O)(C7=CC=C(C)C=C7)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 200 mg/mL (279.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3989 mL | 6.9945 mL | 13.9889 mL | 34.9724 mL |
| 5 mM | 0.2798 mL | 1.3989 mL | 2.7978 mL | 6.9945 mL | |
| 10 mM | 0.1399 mL | 0.6994 mL | 1.3989 mL | 3.4972 mL | |
| 15 mM | 0.0933 mL | 0.4663 mL | 0.9326 mL | 2.3315 mL | |
| 20 mM | 0.0699 mL | 0.3497 mL | 0.6994 mL | 1.7486 mL | |
| 25 mM | 0.0560 mL | 0.2798 mL | 0.5596 mL | 1.3989 mL | |
| 30 mM | 0.0466 mL | 0.2331 mL | 0.4663 mL | 1.1657 mL | |
| 40 mM | 0.0350 mL | 0.1749 mL | 0.3497 mL | 0.8743 mL | |
| 50 mM | 0.0280 mL | 0.1399 mL | 0.2798 mL | 0.6994 mL | |
| 60 mM | 0.0233 mL | 0.1166 mL | 0.2331 mL | 0.5829 mL | |
| 80 mM | 0.0175 mL | 0.0874 mL | 0.1749 mL | 0.4372 mL | |
| 100 mM | 0.0140 mL | 0.0699 mL | 0.1399 mL | 0.3497 mL |
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