CPD-002
CPD-002 is an inhibitor for vascular endothelial growth factor receptor 2 (VEGFR 2), that inhibits angiogenesis through inhibition of VEGFR2/PI3K/AKT signaling pathway. CPD-002 exhibits anti-inflammatory activity and attenuates rheumatoid arthritis.
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- CAS No.: 2617376-08-4
- Formule: C17H16N4O2S
- Masse moléculaire:340.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
150 nM
Compound: 6
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Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay
Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay
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[PMID: 37216810] |
CPD-002 (0-64 μM, 24-48 h) exhibits cytotoxicity for cells HUVECs and MH7A, in a dose-dependent manner[1].
CPD-002 (0-8 μM, 24 h) inhibits VEGF-induced cell migration and invasion of HUVECs, through suppression of F-actin expression, and chemotactic response to MH7A cell-released chemoattractants[1].
CPD-002 (0-8 μM) exhibits anti-inflammatory activity through inhibition of the inflammatory mediators like TNF-α, IL-1β, IL-6, IL-8, MMP2 and MMP9, and thus inhibits synovial angiogenesis[1].
CPD-002 (0-8 μM, 9 days) inhibits HUVECs tube formation and aortic ring sprout formation in ex vivo rat aortic ring assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVECs and MH7A
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Concentration:0-64 μM
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Incubation Time:24-48 h
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Result:Inhibited cell viability in a dose-dependent manner.
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Cell Line:HUVECs
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Concentration:0-8 μM
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Incubation Time:24 h
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Result:Inhibited HUVECs migration in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:adjuvant-induced arthritis (AIA) Sprague Dawley rats models[1]
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Dosage:15-60 mg/kg
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Administration:i.p., once daily for 14 days
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Result:Ameliorated paw swelling, joint damage, and synovial angiogenesis.
Chemical Information
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CAS No. 2617376-08-4
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Masse moléculaire 340.40
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Formule C17H16N4O2S
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SMILES
CNC(C1=CC=CC=C1SC2=CC3=C(C(NC(C)=O)=NN3)C=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CPD-002 Related Classifications
HY-163533 Related Classifications
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