Cyjohnphos
Based on 1 Customer Validation
CyJohnPhos (2-(Dicyclohexylphosphino)biphenyl) is an organophosphine ligand. Gold (I) complexes derived from CyJohnPhos exhibit anti-colon cancer activity, inhibit the enzymatic activities of COX-1/COX-2 and TrxR, upregulate ROS levels, induce cell apoptosis, and some derivatives can induce cell cycle arrest. CyJohnPhos can serve as an intermediate for research related to organic synthesis.
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- Pureté : 98.0%
- CAS No.: 247940-06-3
- Formule: C24H31P
- Masse moléculaire:350.49
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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(Rac)-BINAPIsomer
Activité biologique
Description
In Vitro
CyJohnPhos-derived gold (I) complexes exhibit antiproliferative activity against Caco-2/TC7 colon cancer cells. The representative complex [Au (L4)(CyJohnPhos)]SbF6 (4a) has a selectivity index of 7.47. It inhibits COX-1, COX-2 and TrxR, increases intracellular ROS levels in a concentration-dependent manner, induces tumor cell apoptosis, and triggers G1-phase cell cycle arrest[1].
CyJohnPhos (2-(dicyclohexylphosphino) bipheny) (10 mol %) catalyzes the direct arylation of N-substituted indoles, N-substituted pyrroles, and furan substrates with aryl chlorides[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 247940-06-3
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Appearance Solid
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Masse moléculaire 350.49
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Formule C24H31P
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Color White to off-white
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SMILES
C1(C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2)=CC=CC=C1
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Synonyms
2-(Dicyclohexylphosphino)biphenyl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Pureté et documentation
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Fiche technique (283 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyjohnphos Related Classifications
HY-W002849 Related Classifications
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