EBI3 - Epstein-Barr virus induced 3 Gene

Also Known as IL27B; IL35B; IL-27B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10148

About EBI3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,229,523-4,237,528 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 23 paralogues. Biased expression in placenta (RPKM 82.3), spleen (RPKM 9.3) and 2 other tissues.

Summary

This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus Infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the JAK/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

EBI3 Products (1)

mRNA	Protein	Name
NM_005755.3	NP_005746.2	interleukin-27 subunit beta precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables cytokine receptor activity	IPI IPI: Inferred from physical interaction	9342359	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9342359	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EBI3 Protein Structure

fn3

0
100
200
229 a.a.

Protein Preferred Names	Protein Names
interleukin-27 subunit beta	EBV-induced gene 3 protein

Recombinant EBI3 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70338	IL-35 Protein, Human (HEK293, Fc)	P29459 (R23-S219)&Q14213 (R21-K229)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73199	IL-27 Protein, Human (CHO, His)	Q14213/NP_005746.2 (R21-K229)&Q8NEV9/NP_663634.2 (F29-P243)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73880	IL-35 Protein, Human (HEK293, Flag-His)	P29459 (R23-S219)&Q14213 (R21-K229)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73882	IL-35 Protein, Human (HEK293, His, hFc-Flag)	P29459 (R23-S219)&Q14213 (R21-K229)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700118AF	Animal-Free IL-27 beta/EBI3 Protein, Human (His)	Q14213 (R21-K229)	≥ 95%, as determined by reducing SDS-PAGE.

EBI3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82947	EBI3 Antibody (YA2692)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS04128	EBI3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17022	Ebi3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23465	Ebi3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EBI3	RGD	RGD:1589467
Mus musculus	EBI3	MGD	MGI:1354171