Ptprd - protein tyrosine phosphatase, receptor type, D Gene

Also Known as R-PTP-delta; 1110002J03Rik; 3000002J10Rik; B230219D21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19266

Summary

Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and regulation of synapse assembly. Acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT and regulation of immune response. Located in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PTPRD (protein tyrosine Phosphatase receptor type D). [provided by Alliance of Genome Resources, Apr 2022]

Ptprd Products (7)

mRNA Protein Name
NM_001352628.1 NP_001339557.1 receptor-type tyrosine-protein phosphatase delta isoform 2 precursor
NM_001352629.1 NP_001339558.1 receptor-type tyrosine-protein phosphatase delta isoform 3 precursor
NM_001352630.1 NP_001339559.1 receptor-type tyrosine-protein phosphatase delta isoform 4 precursor
NM_001368991.1 NP_001355920.1 receptor-type tyrosine-protein phosphatase delta isoform 5 precursor
NM_001368992.1 NP_001355921.1 receptor-type tyrosine-protein phosphatase delta isoform 6 precursor
NM_001368993.1 NP_001355922.1 receptor-type tyrosine-protein phosphatase delta isoform 7 precursor
NM_011211.4 NP_035341.2 receptor-type tyrosine-protein phosphatase delta isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
21940441 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21940441 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
21940441 MGI
Biological Process GO Annotation Evidence Références Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
21940441 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
10856223 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10856223 MGI
acts upstream of or within negative regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
24843164 MGI
involved in neuron differentiation IDA
IDA: Inferred from direct assay
21940441 MGI
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
21940441 MGI
involved in positive regulation of dendritic spine morphogenesis IDA
IDA: Inferred from direct assay
21940441 MGI
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
25908590 MGI
involved in presynaptic membrane assembly IDA
IDA: Inferred from direct assay
21940441 MGI
involved in presynaptic membrane assembly IMP
IMP: Inferred from mutant phenotype
21940441 MGI
acts upstream of or within regulation of immune response IMP
IMP: Inferred from mutant phenotype
24843164 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: Inferred from direct assay
22357843 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
22357843 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
21940441 MGI
involved in trans-synaptic signaling IDA
IDA: Inferred from direct assay
32347567 MGI
involved in trans-synaptic signaling IEP
IEP: Inferred from expression pattern
32347567 MGI
involved in trans-synaptic signaling IMP
IMP: Inferred from mutant phenotype
32347567 MGI
Cellular Component GO Annotation Evidence Références Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
10856223 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
10856223 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22357843 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22357843 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
10856223 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: Inferred from mutant phenotype
10856223 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
29024665 MGI
is active in presynaptic membrane IMP
IMP: Inferred from mutant phenotype
32347567 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase delta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-115496 7-BIA Inhibitor 98.0% Unkown
HY-RS11436 PTPRD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17557 Ptprd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24015 Ptprd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28227 Ptprs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprd NCBI NCBI:5789