Lamp2 - lysosomal-associated membrane protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24944

Summary

Predicted to enable enzyme binding activity and protein domain specific binding activity. Involved in chaperone-mediated Autophagy. Acts upstream of or within protein targeting to lysosome involved in chaperone-mediated Autophagy. Located in endosome; lysosomal matrix; and lysosomal membrane. Colocalizes with membrane raft. Used to study Danon disease; cholestasis; chronic conjunctivitis; cognitive disorder; and hypertrophic cardiomyopathy. Biomarker of myocardial infarction and sciatic neuropathy. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lamp2 Products (1)

mRNA Protein Name
NM_017068.3 NP_058764.3 lysosome-associated membrane glycoprotein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12505983 RGD
Biological Process GO Annotation Evidence Références Source
involved in chaperone-mediated autophagy IDA
IDA: Inferred from direct assay
11082038 RGD
acts upstream of or within protein targeting to lysosome involved in chaperone-mediated autophagy IGI
IGI: Inferred from genetic interaction
18644871 RGD
acts upstream of or within protein targeting to lysosome involved in chaperone-mediated autophagy IMP
IMP: Inferred from mutant phenotype
18644871 RGD
Cellular Component GO Annotation Evidence Références Source
located in endosome IDA
IDA: Inferred from direct assay
16085051 RGD
located in lysosomal matrix IDA
IDA: Inferred from direct assay
18644871 RGD
located in lysosomal membrane IDA
IDA: Inferred from direct assay
8662539 RGD
located in membrane raft IMP
IMP: Inferred from mutant phenotype
20797626 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysosome-associated membrane glycoprotein 2

  • CD107 antigen-like family member B

  • LAMP-2

  • LGP-110

  • LGP-96

  • LGP-B

  • lysosomal membrane glycoprotein 2

  • lysosomal membrane glycoprotein type B

  • lysosome-associated membrane protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-134923 CA77.1 Inducer 99.92% Unkown
HY-112483 QX77 Inducer 99.48% Unkown
HY-184300 PDL1 degrader-4 Degrader / Unkown
HY-RS07510 LAMP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17112 Lamp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23557 Lamp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lamp2 NCBI NCBI:3920
Macaca fascicularis Lamp2 NCBI NCBI:102119735
Mus musculus Lamp2 NCBI NCBI:16784