KIF11 - kinesin family member 11 Gene

Also Known as EG5; HKSP; KNSL1; MCLMR; TRIP5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3832

About KIF11

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:92,593,130-92,655,395 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues, 41 paralogues and is associated with 4 phenotypes. Broad expression in lymph node (RPKM 9.9), bone marrow (RPKM 8.6) and 18 other tissues.

Summary

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell Mitosis. [provided by RefSeq, Jul 2008]

KIF11 Products (1)

mRNA	Protein	Name
NM_004523.4	NP_004514.2	kinesin-like protein KIF11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21303978	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19001501	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in mitotic spindle assembly	IDA IDA: Inferred from direct assay	19001501	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in regulation of mitotic centrosome separation	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	14718566	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in microtubule	IDA IDA: Inferred from direct assay	21525035	GOA
part of protein-containing complex	IPI IPI: Inferred from physical interaction	17707232	GOA
located in spindle	IDA IDA: Inferred from direct assay	19001501	GOA
colocalizes with spindle microtubule	IDA IDA: Inferred from direct assay	14718566	GOA
colocalizes with spindle pole	IDA IDA: Inferred from direct assay	14718566	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF11 Protein Structure

Kinesin

Microtub_bind

0
200
400
600
800
1000
1056 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF11	TR-interacting protein 5

KIF11 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80647	Eg5 Antibody (YA776)	WB, ICC/IF, IP	Human
HY-P80647A	Eg5 Antibody (YA776)(PBS only)	WB, ICC/IF, IP	Human
HY-P85489	Eg5 Antibody (YA5181)	WB, IP, ICC/IF	Human

Related Diseases

Diseases	Alias
Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Mental Retardation	Lymphedema, Microcephaly And Chorioretinopathy Syndrome Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Intellectual Disability MCLMR Microcephaly, Lymphedema, Chorioretinal Dysplasia Syndrome Mlcrd Syndrome Cdmmr Syndrome Lymphedema And Retinal Folds With Microcephaly And Microphthalmos Chorioretinal Dysplasia-Microcephaly-Mental Retardation Syndrome Microcephaly Lymphedema Chorioretinal Dysplasia Microcephaly And Chorioretinopathy With Or Without Mental Retardation, Autosomal Dominant Lymphedema, Microcephaly, Chorioretinopathy Syndrome Lymphedema And Retinal Folds With Ficrocephaly And Microphthalmos Chorioretinal Dysplasia-Microcephaly-Intellectual Disability Syndrome Microcephaly-Lymphedema-Chorioretinopathy Syndrome Mlcrd Lymphedema Microcephaly Chorioretinopathy Syndrome Microcephaly Lymphedema Chorioretinal Dysplasia Syndrome Microcephaly With Or Without Chorioretinopathy, Lymphedema Or Intellectual Disability Microcephaly With/Without Chorioretinopathy, Lymphedema, Or Mental Retardation
Syndromic Rod-Cone Dystrophy	Syndromic Retinitis Pigmentosa
Microcephaly And Chorioretinopathy 1
Microcephaly And Chorioretinopathy, Autosomal Recessive, 1	MCCRP1 Microcephaly And Chorioretinopathy, Autosomal Recessive, Type 1 Chorioretinal Dysplasia-Microcephaly-Mental Retardation Syndrome Lymphedema, Microcephaly And Chorioretinopathy Syndrome
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Congenital Lymphedema	Lymphedema, Congenital Milroy Disease
Microcephaly, Autosomal Dominant	Autosomal Dominant Microcephaly Microcephaly Autosomal Dominant Autosomal Dominant Primary Microcephaly Microcephaly With Autosomal Dominant Inheritance
Astigmatism
Invasive Bladder Transitional Cell Carcinoma	Invasive Bladder Urothelial Carcinoma Infiltrating Bladder Urothelial Carcinoma
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS07255	KIF11 Human Pre-designed siRNA Set A		/	Unkown
HY-RS18526	Kif11 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25008	Kif11 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KIF11	VGNC	VGNC:42379
Rattus norvegicus	KIF11	RGD	RGD:621258
Macaca mulatta	KIF11	VGNC	VGNC:74030
Bos taurus	KIF11	VGNC	VGNC:30580
Mus musculus	KIF11	MGD	MGI:1098231
Felis catus	KIF11	VGNC	VGNC:67971
Others	KIF11	NCBI