Griselimycin
Based on 1 Customer Validation
Griselimycin is a cyclic lipopeptide produced by Streptomyces. Griselimycin specifically binds to the sliding clamp of bacterial DNA polymerase and does not interact with human PCNA. Griselimycin exhibits potent antibacterial activity against Mycobacterium tuberculosis (including drug-resistant strains) and a variety of Gram-negative bacteria.
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- Pureté: 98.2%
- CAS No.: 26034-16-2
- Formule: C57H96N10O12
- Masse moléculaire:1113.43
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Griselimycin (0-200 μM) binds to β-clamp homologs from various Gram-negative and Gram-positive bacteria with high selectivity and variable affinities ranging from submicromolar to nanomolar, among which the interaction with Bartonella birtlesii β-clamp is the strongest (Kd = 6.9 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 26034-16-2
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Appearance Solid
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Masse moléculaire 1113.43
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Formule C57H96N10O12
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Color White to off-white
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (258 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Holzgrabe U, et al. New Griselimycins for Treatment of Tuberculosis. Chem Biol. 2015;22(8):981-982. [Content Brief]
[2]. Fenwick MK, et al. Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens. Commun Biol. 2024;7(1):1622. Published 2024 Dec 5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Griselimycin Related Classifications
HY-125576 Related Classifications
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