HX630
HX630 is a potent retinoic acid X receptor (RXR) agonist, can induce apoptosis, has anti-tumor effect, and can be used in Cushing's disease research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 188844-52-2
- Formule: C28H27NO2S
- Masse moléculaire:441.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
HX630 (0.1-10 μM, 96 h) can dose-dependently inhibit cell proliferation and induce apoptosis of AtT20 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AtT20 cells
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Concentration:0.1, 1, 5, 10 μM
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Incubation Time:96 h
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Result:Significantly inhibited AtT20 cell proliferation at 10 μM.
Decreased Pomc mRNA expression and ACTH secretion in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c-nu mice (nu/nu) with AtT20 cells[1]
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Dosage:5 mg/kg
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Administration:i.p., 3 times a week for 3 weeks
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Result:Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different.
Chemical Information
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CAS No. 188844-52-2
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Masse moléculaire 441.58
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Formule C28H27NO2S
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SMILES
O=C(O)C1=CC=C(C(C2=C3)=NC4=CC=CC=C4SC2=CC5=C3C(C)(C)CCC5(C)C)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HX630 Related Classifications
HY-108520 Related Classifications
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