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Cat. No.: HY-186309

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ISRACT-01

ISRACT-01 is an integrated stress response (ISR) activator. ISRACT-01 has a K_d of 557 nM for eIF2B^Δ-latch. ISRACT-01 cooperates with eIF2-P to inhibit guanine nucleotide exchange factor (GEF) activity by specifically binding to and stabilizing the inactive conformation (I-state) of eIF2B. ISRACT-01 can be used in studies related to amyotrophic lateral sclerosis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₃₀H₃₂Cl₂N₂O₄
Masse moléculaire:555.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ISRACT-01 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

eIF2BΔ-latch

557 nM (Kd)

In Vitro

ISRACT-01 (2.4 μM; 5 days) protects BJ fibroblasts treated with Tunicamycin (HY-A0098) from apoptosis^[1].
ISRACT-01 (2-10 μM; 30 min-3 h) inhibits polyribosome formation and promotes the accumulation of ATF4 protein expression in wild-type mouse fibroblasts^[1].
The K_d value for the binding of FAM-ISRACT-01 (2.5 nM; 30 min) to the eIF2B^Δ-latch decamer is 557 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

BJ fibroblasts
Concentration:

2.4 μM (pre-incubation concentration 3 μM)
Incubation Time:

Pre-incubated for 4 h, recorded over 5 days
Result:

Protected the cells from tunicamycin-induced apoptosis.

Western Blot Analysis^[1]

Cell Line:

Wild-type mouse embryonic fibroblasts (MEFs, Eif2s1 S51/S51)
Concentration:

2 μM, 10 μM
Incubation Time:

3 h
Result:

Significantly increased the expression level of ATF4 protein.

Chemical Information

Masse moléculaire 555.49
Formule C₃₀H₃₂Cl₂N₂O₄
SMILES

O=C(CCOC1=CC=C(Cl)C=C1)N[C@H]2CC[C@H](N(CC3=CC=CC=C3)C(COC4=CC=C(Cl)C=C4)=O)CC2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Dalwadi U, et al. Allosteric disordering of eIF2B regulates the integrated stress response. Nature chemical biology. 2026 Jun 29.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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