Kigamicin D
Kigamicin D shows activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 0.025-0.78 μg/mL. Kigamicin D also shows effect against L-1210 LB32T and other genera tumor cells with IC50 of 1 μg/mL.
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- CAS No.: 680571-52-2
- Formule: C48H59NO19
- Masse moléculaire:953.98
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 680571-52-2
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Masse moléculaire 953.98
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Formule C48H59NO19
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SMILES
OC1=C2C3=C(OCO[C@]3([H])CC4=CC(C[C@@]5(N(CCO5)C6=O)C)=C6C(O)=C42)C7=C1C(C8=C([C@H]([C@@H](C[C@@H]8O)O[C@@H]9O[C@@H]([C@H](CC9)O[C@H]%10C[C@H]([C@@H]([C@H](O%10)C)O[C@H]%11C[C@H]([C@@H]([C@H](O%11)C)O)OC)OC)C)O)O7)=O
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Structure Classification
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Initial Source
Amycolatopsis sp. ML630-mF1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Kigamicin D Related Classifications
HY-N14484 Related Classifications
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