LT-850-166
LT-850-166 is a potent FLT3 inhibitor with the capacity of overcoming a variety of FLT3 mutations.
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- CAS No.: 3031480-22-2
- Formule: C30H29Cl2N7O
- Masse moléculaire:574.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3663 nM
Compound: 67
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| BaF3 | IC50 |
<1.5 nM
Compound: 67
|
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| BaF3 | IC50 |
<1.5 nM
Compound: 67
|
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-Y842H mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-Y842H mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| BaF3 | IC50 |
<1.5 nM
Compound: 67
|
Antiproliferative activity against mouse BaF3 cells harboring FLT3-TEL-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-TEL-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| BaF3 | IC50 |
4095 nM
Compound: 67
|
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
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[PMID: 34550682] |
| BaF3 | IC50 |
42.4 nM
Compound: 67
|
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-N676D mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-N676D mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
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[PMID: 34550682] |
| BaF3 | IC50 |
7.6 nM
Compound: 67
|
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| BaF3 | IC50 |
8.3 nM
Compound: 67
|
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-F691L mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-F691L mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| HCT-116 | IC50 |
>10000 nM
Compound: 67
|
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| MDA-MB-231 | IC50 |
3853 nM
Compound: 67
|
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| MKN-45 | IC50 |
4029 nM
Compound: 67
|
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
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[PMID: 34550682] |
| MOLM-13 | IC50 |
9.85 nM
Compound: 67
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Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
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[PMID: 34550682] |
| MV4-11 | IC50 |
2.93 nM
Compound: 67
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| NB-4 | IC50 |
>5000 nM
Compound: 67
|
Antiproliferative activity against human NB-4 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human NB-4 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
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[PMID: 34550682] |
| Panc02 | IC50 |
2745 nM
Compound: 67
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Antiproliferative activity against mouse Panc02 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse Panc02 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| THP-1 | IC50 |
>5000 nM
Compound: 67
|
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
| U-937 | IC50 |
>2000 nM
Compound: 67
|
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
|
[PMID: 34550682] |
Chemical Information
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CAS No. 3031480-22-2
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Masse moléculaire 574.50
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Formule C30H29Cl2N7O
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SMILES
O=C(NC1=NNC(C2=CC3=C(C=C2)N=CN3CC4=C(C=CC=C4Cl)Cl)=C1)C5=CC=C(C=C5)N6CCN(CC6)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Select Batch:
Pureté:
99.98%
Assay:
99.98%
ee.:
99.98%
Références
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LT-850-166 Related Classifications
HY-139619 Related Classifications
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