MT-7
MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules.
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- CAS No.: 946507-08-0
- Formule: C22H17N3O2
- Masse moléculaire:355.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
1.8 μM
Compound: 1a (MT-7)
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Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
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[PMID: 24360827] |
MT-7 (0-8µM; 72 h) inhibits cell proliferation with IC50 values ranging from 0.85 μM to 5.01 μM for HeLa, HL60, A549,MDA-MB-468, Lovo, HCT116, SMMC-7721, HO-8910, A375 and SG7901 cells[1].
MT-7 (5 μM; 12 h) induces cell cycle arrest at the G2/M phase[1].
MT-7 (5 μM; 1.5, 3, 6, 12 h) increases the gene expression of THBS, IL6 and PHLDA1, dereases the gene expression of COX5B, RPS11 and CYP26A1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:5 μM
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Incubation Time:12 h
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Result:Induced cell cycle arrest at G2/M phase and decreased the protein expression of MPM-2, Pi-H3.
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Cell Line:HeLa cells
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Concentration:5 μM
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Incubation Time:1.5, 3, 6, 12 h
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Result:Upregulated the gene expression of THBS, IL6 and PHLDA1, doen-regulated the gene expression of COX5B, RPS11 and CYP26A1.
Chemical Information
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CAS No. 946507-08-0
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Masse moléculaire 355.39
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Formule C22H17N3O2
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SMILES
O=C1N(C2=C(C3=C1C=CC=C3)N=C4N2C=CC=C4)CC5=CC=C(C=C5)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MT-7 Related Classifications
HY-122249 Related Classifications
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