Neoaureothin
Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50=1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.
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- CAS No.: 59795-94-7
- Formule: C28H31NO6
- Masse moléculaire:477.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 59795-94-7
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Masse moléculaire 477.55
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Formule C28H31NO6
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SMILES
CC(C1=O)=C([C@@](OC/2)([H])CC2=C\C(C)=C\C(C)=C\C(C)=C\C(C=C3)=CC=C3[N+]([O-])=O)OC(OC)=C1C
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Synonyms
NSC 260179; Spectinabilin
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neoaureothin Related Classifications
HY-N8504 Related Classifications
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