Phenazostatin A
Phenazostatin A is a phenazine Substance that has the protective effect of new neuron cells. Phenazostatin A can scavenge free radicals, protect N18-RE 105 nerve cells from glutamate toxicity, and inhibit lipid peroxidation. Phenazostatin A inhibits glutamate toxicity in N18-RE-105 cells with an EC50 of 0.34 μg/mL.
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- CAS No.: 185614-22-6
- Formule: C28H20N4O3
- Masse moléculaire:460.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
Chemical Information
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CAS No. 185614-22-6
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Masse moléculaire 460.48
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Formule C28H20N4O3
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SMILES
O=C(C1=CC=CC2=NC3=C(C(C)OC4=CC=C5N=C6C=CC=CC6=NC5=C4)C=CC=C3N=C21)OC
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Ferroptosis Solutions
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death characterized by lethal lipid peroxidation and sensitivity to suppression by iron chelators or lipophilic radical-trapping antioxidants. The core pathway links cystine uptake through system Xc−, glutathione availability, GPX4-dependent detoxification of phospholipid hydroperoxides, iron-dependent oxidative reactions, and polyunsaturated-phospholipid metabolism into a cell-death program that is biochemically and morphologically distinct from apoptosis, necrosis, and autophagy. The ferroptosis pathway is experimentally linked to phenotype through chemical and genetic perturbation. Erastin induces ferroptosis by inhibiting cystine uptake through system Xc− and weakening antioxidant defenses, while GPX4 inhibition or depletion causes lipid peroxide accumulation and ferroptotic cancer-cell death. ACSL4 and oxidizable arachidonoyl- or adrenoyl-containing phosphatidylethanolamines shape ferroptosis sensitivity by con
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phenazostatin A Related Classifications
HY-N14405 Related Classifications
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