New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp

  • J Antibiot (Tokyo). 1997 Sep;50(9):715-21. doi: 10.7164/antibiotics.50.715.
W G Kim  1 ,  I J Ryoo ,  B S Yun ,  K Shin-ya ,  H Seto ,  I D Yoo
Affiliations
  • 1. Korea Research Institute of Bioscience and Biotechnology, KIST, Yusong, Taejon, Korea.
PMID: 9360614 DOI: 10.7164/antibiotics.50.715
Abstract

Phenazostatins A and B, new diphenazine compounds, were isolated from the culture broth of Streptomyces sp. 833 as new neuronal cell protecting substances which also showed free radical scavenging activity. In the cell assay, phenazostatins A and B inhibited glutamate toxicity in N18-RE-105 cells with EC50 values of 0.34 and 0.33 microM, respectively.

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