IL-35
Interleukin-35 (IL-35) is a heterodimeric anti-inflammatory cytokine of the IL-12 family, uniquely composed of the IL-12α (p35) and EBI3 (IL-27β) subunits. It is not produced by conventional antigen-presenting cells but is a signature mediator of regulatory T cells (Tregs), especially mouse Treg cells that constitutively express both subunits, and also by regulatory B cells and placental trophoblasts. IL-35 signals through two receptor pairs-IL-12Rβ2/gp130 or IL-12Rβ2/IL-12Rβ1-activating STAT1/STAT3/STAT4 heterodimers, a mode of STAT activation unique among cytokines. It suppresses effector T-cell proliferation and Th17 differentiation, converts conventional T cells into IL-35-producing induced Treg (iTr35) cells, dampens autoimmune neuroinflammation and colitis, and curbs antitumor immunity. Consequently, IL-35 simultaneously offers therapeutic promise for autoimmunity and transplant rejection, and represents an obstacle in cancer immunotherapy.
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IL-35 Protéines Recombinantes (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
