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Cat. No.: HY-100857

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PrPSc-IN-1

PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrP^Sc, inhibits its accumulation, with an IC₅₀ of 1.6 μM. Anti-prion activity.

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CAS No.: 1315475-30-9
Formule: C₂₂H₁₇N₅O
Masse moléculaire:367.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PrPSc-IN-1 Chemical Structure

CAS No.: 1315475-30-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrP^Sc, inhibits its accumulation, with an IC₅₀ of 1.6 μM. Anti-prion activity^[1].

IC₅₀ & Target

IC50：1.6 μM (PrP^Sc)^[1]

Chemical Information

CAS No. 1315475-30-9
Masse moléculaire 367.40
Formule C₂₂H₁₇N₅O
SMILES

COC1=CC=C(N2C(C(N/N=C/C3=C(C=CC=C4)C4=NC=C3)=N5)=CC=C2)C5=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zaccagnini L, et al. Identification of novel fluorescent probes preventing PrPSc replication in prion diseases. Eur J Med Chem. 2017 Feb 15;127:859-873. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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