PU-11
PU-11 is a Hsp90α/Hsp90β inhibitor with IC50 values of 18.6 μM and 89.8 μM and Kd values of 2 and 4.2 μM. PU-11 binds to the ATP-binding pocket of Hsp90α and Hsp90β and displays selective binding preference for Hsp90α over Hsp90β, mediated by the nonconserved Hsp90α Ser52 residue. PU-11 can be used for the research of neurodegenerative disorders.
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- CAS No.: 1454619-18-1
- Formule: C19H23N5O3
- Masse moléculaire:369.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
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HSP90α 18.6 μM (IC50) |
HSP90β 89.8 μM (IC50) |
HSP90α 2 μM (Kd) |
HSP90β 4.2 μM (Kd) |
In Vitro
PU-11 (Compound PU-11-trans) (30.1-50.7 μM) binds to purified human Hsp90α NTD with a Kd of 2.0 ± 0.14 μM and an IC50 of 18.6 μM, exhibiting selective affinity for this paralog[1].
PU-11 (93.3-97.8 μM) binds to purified human Hsp90β NTD with a Kd of 4.2 ± 0.74 μM and an IC50 of 89.8 μM, showing lower affinity than for Hsp90α[1].
PU-11 (33.0-41.8 μM) binds to purified human Hsp90αS52A mutant NTD with a Kd of 4.2 ± 0.03 μM, matching its affinity for wild-type Hsp90β[1].
PU-11 shows IC50 values of 111.4 ± 9.7 and 172.9 ± 7.3 μM for Grp94 and Trap-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1454619-18-1
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Masse moléculaire 369.43
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Formule C19H23N5O3
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SMILES
C(/C=C/C)N1C=2C(N=C1CC3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=CN2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PU-11 Related Classifications
HY-116053 Related Classifications
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