PUMA2A
PUMA2A is a PUMA BH3-only peptide. PUMA2A can be used as a negative control in Cytochrome C release assays and BH3 profiling. PUMA2A can be used in the research of chronic myeloid leukemia.
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- Formule: C96H156N34O30S
- Masse moléculaire:2298.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
PUMA-2A (1-100 μM; 2 h) does not induce significant mitochondrial membrane potential loss in K562 CML cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 2298.54
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Formule C96H156N34O30S
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Sequence
Ac-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Ala-Arg-Arg-Met-Ala-Ala-Asp-Leu-Asn-Ala-NH2
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Sequence Shortening
Ac-EQWAREIGAQARRMAADLNA-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[2]. Lucas CM, et al. High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. Leukemia. 2016;30(6):1273-1281. [Content Brief]
[3]. Butterworth M, et al. BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells. Br J Cancer. 2016;114(6):638-641. [Content Brief]
[4]. Alhuthali HM, et al. The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun. BMC Cancer. 2020;20(1):629. Published 2020 Jul 7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PUMA2A Related Classifications
HY-P11705 Related Classifications
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